Umod - uromodulin Gene

Mus musculus

Also known as THP; Urehd1; urehr4

Gene ID: 22242 | Gene type: protein coding

About Umod

Summary

This gene encodes a glycoprotein that is the most abundant protein in mammalian urine under physiological conditions. It is synthesized in the kidney as a glycosyl-phosphatidylinositol anchored protein and released into urine as a soluble form by proteolytic cleavage. It is thought to regulate water and salt balance in the thick ascending limb of Henle and to protect against urinary tract Infection and calcium oxalate crystal formation. In mouse deficiency of this gene is associated with increased susceptibility to Bacterial infections and formation of calcium crystals in kidneys. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Umod Products(2)

mRNA	Protein	Name
NM_001278605.1	NP_001265534.1	uromodulin preproprotein
NM_009470.5	NP_033496.1	uromodulin preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	28437467	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within ERAD pathway	IMP IMP: Inferred from mutant phenotype	28437467	MGI
acts upstream of RNA splicing	IMP IMP: Inferred from mutant phenotype	28437467	MGI
acts upstream of or within apoptotic process	IMP IMP: Inferred from mutant phenotype	29145399	MGI
acts upstream of or within apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	28990932	MGI
acts upstream of or within autophagy	IMP IMP: Inferred from mutant phenotype	28990932	MGI
acts upstream of or within calcium ion homeostasis	IMP IMP: Inferred from mutant phenotype	20591941	MGI
acts upstream of or within cellular response to stress	IMP IMP: Inferred from mutant phenotype	28785050	MGI
acts upstream of or within cellular response to unfolded protein	IMP IMP: Inferred from mutant phenotype	28437467	MGI
acts upstream of chaperone-mediated protein folding	IMP IMP: Inferred from mutant phenotype	28437467	MGI
acts upstream of or within chemical homeostasis	IMP IMP: Inferred from mutant phenotype	17264314	MGI
acts upstream of or within chemokine production	IMP IMP: Inferred from mutant phenotype	28785050	MGI
acts upstream of or within chloride ion homeostasis	IMP IMP: Inferred from mutant phenotype	29357410	MGI
acts upstream of or within citric acid secretion	IMP IMP: Inferred from mutant phenotype	20591941	MGI
acts upstream of or within collecting duct development	IMP IMP: Inferred from mutant phenotype	17898038	MGI
acts upstream of or within connective tissue replacement	IMP IMP: Inferred from mutant phenotype	28785050	MGI
acts upstream of or within defense response to Gram-negative bacterium	IMP IMP: Inferred from mutant phenotype	14665435	MGI
acts upstream of or within endoplasmic reticulum organization	IMP IMP: Inferred from mutant phenotype	28437467	MGI
acts upstream of or within gene expression	IMP IMP: Inferred from mutant phenotype	15522986	MGI
acts upstream of or within glomerular filtration	IMP IMP: Inferred from mutant phenotype	15522986	MGI
acts upstream of or within inflammatory response	IMP IMP: Inferred from mutant phenotype	28785050	MGI
acts upstream of or within intracellular calcium ion homeostasis	IMP IMP: Inferred from mutant phenotype	17898038	MGI
acts upstream of or within intracellular chloride ion homeostasis	IDA IDA: Inferred from direct assay	21737451	MGI
acts upstream of or within intracellular chloride ion homeostasis	IMP IMP: Inferred from mutant phenotype	17898038	MGI
acts upstream of or within intracellular phosphate ion homeostasis	IMP IMP: Inferred from mutant phenotype	17898038	MGI
acts upstream of or within intracellular sodium ion homeostasis	IMP IMP: Inferred from mutant phenotype	17898038	MGI
acts upstream of or within juxtaglomerular apparatus development	IMP IMP: Inferred from mutant phenotype	15522986	MGI
acts upstream of or within kidney development	IMP IMP: Inferred from mutant phenotype	28990932	MGI
acts upstream of or within lipid metabolic process	IMP IMP: Inferred from mutant phenotype	28785050	MGI
acts upstream of or within loop of Henle development	IMP IMP: Inferred from mutant phenotype	15522986	MGI
involved in metanephric ascending thin limb development	IEP IEP: Inferred from expression pattern	18618131	MGI
involved in metanephric distal convoluted tubule development	IEP IEP: Inferred from expression pattern	18618131	MGI
involved in metanephric thick ascending limb development	IEP IEP: Inferred from expression pattern	18618131	MGI
acts upstream of or within micturition	IMP IMP: Inferred from mutant phenotype	19214995	MGI
involved in monoatomic ion homeostasis	IMP IMP: Inferred from mutant phenotype	15327412	MGI
acts upstream of or within multicellular organismal response to stress	IMP IMP: Inferred from mutant phenotype	19214995	MGI
acts upstream of or within multicellular organismal-level homeostasis	IMP IMP: Inferred from mutant phenotype	29145399	MGI
acts upstream of or within multicellular organismal-level water homeostasis	IMP IMP: Inferred from mutant phenotype	29357410	MGI
acts upstream of or within organ or tissue specific immune response	IMP IMP: Inferred from mutant phenotype	28990932	MGI
acts upstream of or within peptidyl-threonine phosphorylation	IMP IMP: Inferred from mutant phenotype	30007527	MGI
acts upstream of or within phosphate ion homeostasis	IMP IMP: Inferred from mutant phenotype	20591941	MGI
acts upstream of or within potassium ion homeostasis	IMP IMP: Inferred from mutant phenotype	29357410	MGI
acts upstream of or within protein localization to vacuole	IMP IMP: Inferred from mutant phenotype	21081491	MGI
acts upstream of or within positive effect protein phosphorylation	IDA IDA: Inferred from direct assay	21737451	MGI
acts upstream of or within positive effect protein phosphorylation	IMP IMP: Inferred from mutant phenotype	21737451	MGI
acts upstream of or within protein transport into plasma membrane raft	IMP IMP: Inferred from mutant phenotype	29357410	MGI
acts upstream of or within regulation of blood pressure	IMP IMP: Inferred from mutant phenotype	29357410	MGI
acts upstream of or within regulation of protein transport	IMP IMP: Inferred from mutant phenotype	29145399	MGI
acts upstream of or within regulation of urine volume	IMP IMP: Inferred from mutant phenotype	29145399	MGI
acts upstream of or within renal sodium ion absorption	IDA IDA: Inferred from direct assay	21737451	MGI
acts upstream of or within renal sodium ion absorption	IMP IMP: Inferred from mutant phenotype	21737451	MGI
acts upstream of or within renal urate salt excretion	IMP IMP: Inferred from mutant phenotype	29357410	MGI
acts upstream of or within renal water homeostasis	IMP IMP: Inferred from mutant phenotype	15522986	MGI
acts upstream of or within response to diuretic	IMP IMP: Inferred from mutant phenotype	29357410	MGI
acts upstream of or within response to endoplasmic reticulum stress	IMP IMP: Inferred from mutant phenotype	28990932	MGI
acts upstream of or within response to lipopolysaccharide	IDA IDA: Inferred from direct assay	3356692	MGI
acts upstream of or within response to unfolded protein	IMP IMP: Inferred from mutant phenotype	29145399	MGI
acts upstream of or within response to water deprivation	IMP IMP: Inferred from mutant phenotype	15522986	MGI
acts upstream of or within response to xenobiotic stimulus	IMP IMP: Inferred from mutant phenotype	30007527	MGI
acts upstream of or within sodium ion homeostasis	IMP IMP: Inferred from mutant phenotype	29357410	MGI
acts upstream of or within tumor necrosis factor-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	28990932	MGI
acts upstream of or within urate transport	IMP IMP: Inferred from mutant phenotype	29357410	MGI
acts upstream of or within urea transmembrane transport	IMP IMP: Inferred from mutant phenotype	17264314	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	21397062	MGI
located in cilium	IDA IDA: Inferred from direct assay	20172860	MGI
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	22237754	MGI
located in extracellular space	IDA IDA: Inferred from direct assay	22237754	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	22237754	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

uromodulin

Tamm-Horsfall urinary glycoprotein

uromucoid

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15459	UMOD Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Umod	NCBI	NCBI:7369

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