Unc13b - unc-13 homolog B Gene

Also Known as Unc13a; Unc13h1; Unc13h2; Munc13-1; Munc13-2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 22249

Summary

Predicted to enable GTP-dependent protein binding activity; Calmodulin binding activity; and syntaxin-1 binding activity. Involved in several processes, including negative regulation of synaptic plasticity; positive regulation of defense response to bacterium; and synaptic vesicle exocytosis. Acts upstream of or within several processes, including chemical synaptic transmission; innervation; and regulation of short-term neuronal synaptic plasticity. Located in several cellular components, including calyx of Held; early phagosome; and glutamatergic synapse. Is active in hippocampal mossy fiber to CA3 synapse. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and respiratory system. Orthologous to human UNC13B (unc-13 homolog B). [provided by Alliance of Genome Resources, Apr 2022]

Unc13b Products (4)

mRNA Protein Name
NM_001081413.2 NP_001074882.1 protein unc-13 homolog B isoform 2
NM_001310758.1 NP_001297687.1 protein unc-13 homolog B isoform 3
NM_001384106.1 NP_001371035.1 protein unc-13 homolog B isoform 4
NM_021468.3 NP_067443.2 protein unc-13 homolog B isoform 1

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
acts upstream of or within chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
12070347 MGI
NOT involved in dense core granule docking IGI
IGI: Inferred from genetic interaction
26575293 MGI
acts upstream of or within innervation IGI
IGI: Inferred from genetic interaction
15988013 MGI
involved in negative regulation of synaptic plasticity IGI
IGI: Inferred from genetic interaction
23658173 MGI
acts upstream of or within neuromuscular junction development IGI
IGI: Inferred from genetic interaction
15988013 MGI
involved in neuronal dense core vesicle exocytosis IMP
IMP: Inferred from mutant phenotype
23229896 MGI
involved in phagosome maturation IMP
IMP: Inferred from mutant phenotype
23197834 MGI
involved in positive regulation of defense response to bacterium IMP
IMP: Inferred from mutant phenotype
23197834 MGI
acts upstream of or within regulation of short-term neuronal synaptic plasticity IMP
IMP: Inferred from mutant phenotype
11832228 MGI
involved in regulation of short-term neuronal synaptic plasticity IMP
IMP: Inferred from mutant phenotype
19700493 MGI
acts upstream of or within synaptic transmission, glutamatergic IGI
IGI: Inferred from genetic interaction
11792326 MGI
acts upstream of or within synaptic transmission, glutamatergic IMP
IMP: Inferred from mutant phenotype
11832228 MGI
acts upstream of or within synaptic vesicle docking IGI
IGI: Inferred from genetic interaction
19558619 MGI
involved in synaptic vesicle exocytosis IDA
IDA: Inferred from direct assay
19700493 MGI
involved in synaptic vesicle exocytosis IMP
IMP: Inferred from mutant phenotype
19700493 MGI
acts upstream of or within synaptic vesicle priming IMP
IMP: Inferred from mutant phenotype
12070347 MGI
involved in synaptic vesicle priming IMP
IMP: Inferred from mutant phenotype
11832228 MGI
Cellular Component GO Annotation Evidence References Source
is active in calyx of Held IDA
IDA: Inferred from direct assay
23658173 MGI
located in calyx of Held IDA
IDA: Inferred from direct assay
23658173 MGI
located in early phagosome IDA
IDA: Inferred from direct assay
23197834 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
19700493 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
19700493 MGI
is active in hippocampal mossy fiber to CA3 synapse IDA
IDA: Inferred from direct assay
19700493 MGI
is active in hippocampal mossy fiber to CA3 synapse IMP
IMP: Inferred from mutant phenotype
19700493 MGI
located in neuromuscular junction IDA
IDA: Inferred from direct assay
15988013 MGI
is active in presynapse IDA
IDA: Inferred from direct assay
23658173 MGI
located in presynapse IDA
IDA: Inferred from direct assay
23658173 MGI
located in presynaptic active zone IDA
IDA: Inferred from direct assay
22674279 MGI
located in ribbon synapse IDA
IDA: Inferred from direct assay
22674279 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein unc-13 homolog B

  • UNC-13 homolog 1

  • munc13

  • unc13 homolog 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15465 UNC13B Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Unc13b NCBI NCBI:10497