SEMA3D - semaphorin 3D Gene

Homo sapiens

Also known as coll-2; Sema-Z2

Gene ID: 223117 | Gene type: protein coding

About SEMA3D

Cytogenetic location: 7q21.11 Genomic coordinates (GRCh38): 7:84,995,553-85,250,243 (from NCBI)

This gene has 4 transcripts (splice variants), 213 orthologues, 19 paralogues and is associated with 1 phenotype. Biased expression in spleen (RPKM 23.4), thyroid (RPKM 18.9) and 13 other tissues.

Summary

This gene encodes a member of the semaphorin III family of secreted signaling proteins that are involved in axon guidance during neuronal development. The encoded protein contains an N-terminal Sema domain, an immunoglobulin like domain and a C-terminal basic domain. The protein encoded by this gene binds neuropilin and plays an important role in cardiovascular development. [provided by RefSeq, Aug 2016]

SEMA3D Products(5)

mRNA	Protein	Name
NM_001384900.1	NP_001371829.1	semaphorin-3D precursor
NM_001384901.1	NP_001371830.1	semaphorin-3D precursor
NM_001384902.1	NP_001371831.1	semaphorin-3D precursor
NM_001384903.1	NP_001371832.1	semaphorin-3D precursor
NM_152754.3	NP_689967.2	semaphorin-3D precursor

SEMA3D Protein Structure

Sema

V-set

0
200
400
600
777 a.a.

Protein Preferred Names

Protein Names

semaphorin-3D

collapsin 2

Related Diseases

Diseases

Alias

Hirschsprung Disease 1

Hirschsprung Disease	Aganglionic Megacolon
Hscr	Hirschsprung'S Disease
Congenital Megacolon	Congenital Intestinal Aganglionosis
Colonic Aganglionosis	Hirschsprung Disease, Susceptibility To, 1
Hirschsprung Disease, Protection Against	HSCR1
Mgc	Pelvirectal Achalasia
Total Intestinal Aganglionosis	Megacolon, Aganglionic
Macrocolon	Hscr 1
Hirschsprung Disease Type 1	Hirschsprung Disease, Type 1
Congenital Dilatation Of Colon	Aganglionosis
Congenital Aganglionic Megacolon	Aganglionosis Of Colon
Bowel Aganglionosis	Colon Aganglionosis
Hirschsprung Megacolon

Kallmann Syndrome

Hypogonadism With Anosmia	Kallman'S Syndrome
Anosmic Hypogonadism	Anosmic Idiopathic Hypogonadotropic Hypogonadism
Hypogonadotropic Hypogonadism And Anosmia	Hypogonadotropic Hypogonadism-Anosmia Syndrome
Olfacto-Genital Pathological Sequence	Familial Hypogonadism With Anosmia
Kallman Syndrome	Dysplasia Olfactogenitalis Of De Morsier
Kallmann'S Syndrome	Congenital Hypogonadotropic Hypogonadism With Anosmia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12653	SEMA3D Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SEMA3D	MGD	MGI:1860118
Canis familiaris	SEMA3D	VGNC	VGNC:45990
Rattus norvegicus	SEMA3D	RGD	RGD:727939
Macaca mulatta	SEMA3D	VGNC	VGNC:77162
Bos taurus	SEMA3D	VGNC	VGNC:34429
Felis catus	SEMA3D	VGNC	VGNC:64988

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