SEMA3D - semaphorin 3D Gene

Also Known as coll-2; Sema-Z2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 223117

About SEMA3D

Cytogenetic location: 7q21.11 Genomic coordinates (GRCh38): 7:84,995,553-85,250,243 (from NCBI)

This gene has 4 transcripts (splice variants), 213 orthologues, 19 paralogues and is associated with 1 phenotype. Biased expression in spleen (RPKM 23.4), thyroid (RPKM 18.9) and 13 other tissues.

Summary

This gene encodes a member of the semaphorin III family of secreted signaling proteins that are involved in axon guidance during neuronal development. The encoded protein contains an N-terminal Sema domain, an immunoglobulin like domain and a C-terminal basic domain. The protein encoded by this gene binds neuropilin and plays an important role in cardiovascular development. [provided by RefSeq, Aug 2016]

SEMA3D Products (5)

mRNA Protein Name
NM_001384900.1 NP_001371829.1 semaphorin-3D precursor
NM_001384901.1 NP_001371830.1 semaphorin-3D precursor
NM_001384902.1 NP_001371831.1 semaphorin-3D precursor
NM_001384903.1 NP_001371832.1 semaphorin-3D precursor
NM_152754.3 NP_689967.2 semaphorin-3D precursor

SEMA3D Protein Structure

Sema

Sema: Sema domain (70 - 514)

V-set

V-set: Immunoglobulin V-set domain (611 - 671)

  • 0
  • 200
  • 400
  • 600
  • 777 a.a.
Protein Preferred Names Protein Names

semaphorin-3D

  • collapsin 2

Related Diseases

Diseases Alias
Hirschsprung Disease 1

  • Hirschsprung Disease

  • Aganglionic Megacolon

  • Hscr

  • Hirschsprung'S Disease

  • Congenital Megacolon

  • Congenital Intestinal Aganglionosis

  • Colonic Aganglionosis

  • Hirschsprung Disease, Susceptibility To, 1

  • Hirschsprung Disease, Protection Against

  • HSCR1

  • Mgc

  • Pelvirectal Achalasia

  • Total Intestinal Aganglionosis

  • Megacolon, Aganglionic

  • Macrocolon

  • Hscr 1

  • Hirschsprung Disease Type 1

  • Hirschsprung Disease, Type 1

  • Congenital Dilatation Of Colon

  • Aganglionosis

  • Congenital Aganglionic Megacolon

  • Aganglionosis Of Colon

  • Bowel Aganglionosis

  • Colon Aganglionosis

  • Hirschsprung Megacolon
Kallmann Syndrome

  • Hypogonadism With Anosmia

  • Kallman'S Syndrome

  • Anosmic Hypogonadism

  • Anosmic Idiopathic Hypogonadotropic Hypogonadism

  • Hypogonadotropic Hypogonadism And Anosmia

  • Hypogonadotropic Hypogonadism-Anosmia Syndrome

  • Olfacto-Genital Pathological Sequence

  • Familial Hypogonadism With Anosmia

  • Kallman Syndrome

  • Dysplasia Olfactogenitalis Of De Morsier

  • Kallmann'S Syndrome

  • Congenital Hypogonadotropic Hypogonadism With Anosmia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12653 SEMA3D Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus SEMA3D MGD MGI:1860118
Canis familiaris SEMA3D VGNC VGNC:45990
Rattus norvegicus SEMA3D RGD RGD:727939
Macaca mulatta SEMA3D VGNC VGNC:77162
Bos taurus SEMA3D VGNC VGNC:34429
Felis catus SEMA3D VGNC VGNC:64988
Others SEMA3D NCBI