Vax1 - ventral anterior homeobox 1 Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 22326

Summary

This gene encodes a member of the EMX homeobox protein family. The encoded protein functions as a transcription factor which is important in the development of anterior ventral forebrain and visual system. Disruption of this gene causes impairment in the developing forebrain, where the encoded protein is necessary for axon guidance and major tract formation. [provided by RefSeq, Dec 2015]

Vax1 Products (1)

mRNA Protein Name
NM_009501.3 NP_033527.1 ventral anterior homeobox 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription factor activity IMP
IMP: Inferred from mutant phenotype
10601035 MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
15905411 MGI
enables RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
15905411 MGI
enables chromatin DNA binding IDA
IDA: Inferred from direct assay
15905411 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within astrocyte differentiation IMP
IMP: Inferred from mutant phenotype
15590934 MGI
acts upstream of or within axon guidance IMP
IMP: Inferred from mutant phenotype
10601035 MGI
acts upstream of or within brain development IMP
IMP: Inferred from mutant phenotype
10601035 MGI
acts upstream of or within camera-type eye development IGI
IGI: Inferred from genetic interaction
15905411 MGI
acts upstream of or within central nervous system development IMP
IMP: Inferred from mutant phenotype
10601035 MGI
acts upstream of or within negative regulation of neuroblast proliferation IMP
IMP: Inferred from mutant phenotype
15590934 MGI
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
15905411 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
15905411 MGI
acts upstream of or within nervous system development IMP
IMP: Inferred from mutant phenotype
15280216 MGI
acts upstream of neuroblast proliferation IMP
IMP: Inferred from mutant phenotype
15590934 MGI
acts upstream of or within neuroepithelial cell differentiation IMP
IMP: Inferred from mutant phenotype
15590934 MGI
acts upstream of or within neuron migration IMP
IMP: Inferred from mutant phenotype
15280216 MGI
acts upstream of or within roof of mouth development IMP
IMP: Inferred from mutant phenotype
10601035 MGI
acts upstream of or within skeletal muscle cell differentiation IMP
IMP: Inferred from mutant phenotype
22147266 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
17043310 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ventral anterior homeobox 1

  • ventral anterior homeobox containing gene 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15615 VAX1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Vax1 NCBI NCBI:11023