Vax1 - ventral anterior homeobox 1 Gene

Mus musculus

Gene ID: 22326 | Gene type: protein coding

About Vax1

Summary

This gene encodes a member of the EMX homeobox protein family. The encoded protein functions as a transcription factor which is important in the development of anterior ventral forebrain and visual system. Disruption of this gene causes impairment in the developing forebrain, where the encoded protein is necessary for axon guidance and major tract formation. [provided by RefSeq, Dec 2015]

Vax1 Products(1)

mRNA	Protein	Name
NM_009501.3	NP_033527.1	ventral anterior homeobox 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription factor activity	IMP IMP: Inferred from mutant phenotype	10601035	MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	15905411	MGI
enables RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	15905411	MGI
enables chromatin DNA binding	IDA IDA: Inferred from direct assay	15905411	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within astrocyte differentiation	IMP IMP: Inferred from mutant phenotype	15590934	MGI
acts upstream of or within axon guidance	IMP IMP: Inferred from mutant phenotype	10601035	MGI
acts upstream of or within brain development	IMP IMP: Inferred from mutant phenotype	10601035	MGI
acts upstream of or within camera-type eye development	IGI IGI: Inferred from genetic interaction	15905411	MGI
acts upstream of or within central nervous system development	IMP IMP: Inferred from mutant phenotype	10601035	MGI
acts upstream of or within negative regulation of neuroblast proliferation	IMP IMP: Inferred from mutant phenotype	15590934	MGI
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	15905411	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	15905411	MGI
acts upstream of or within nervous system development	IMP IMP: Inferred from mutant phenotype	15280216	MGI
acts upstream of neuroblast proliferation	IMP IMP: Inferred from mutant phenotype	15590934	MGI
acts upstream of or within neuroepithelial cell differentiation	IMP IMP: Inferred from mutant phenotype	15590934	MGI
acts upstream of or within neuron migration	IMP IMP: Inferred from mutant phenotype	15280216	MGI
acts upstream of or within roof of mouth development	IMP IMP: Inferred from mutant phenotype	10601035	MGI
acts upstream of or within skeletal muscle cell differentiation	IMP IMP: Inferred from mutant phenotype	22147266	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	17043310	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

ventral anterior homeobox 1

ventral anterior homeobox containing gene 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15615	VAX1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Vax1	NCBI	NCBI:11023

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