Washc5 - WASH complex subunit 5 Gene

Also Known as strumpellin; E430025E21Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 223593

Summary

Predicted to enable identical protein binding activity. Involved in meiotic spindle assembly; oocyte maturation; and polar body extrusion after meiotic divisions. Acts upstream of or within several processes, including lysosome organization; regulation of actin nucleation; and regulation of vesicle size. Located in endosome. Part of WASH complex. Is expressed in foregut; male reproductive system; nervous system; sensory organ; and vibrissa. Human ortholog(s) of this gene implicated in Ritscher-Schinzel syndrome 1 and hereditary spastic paraplegia 8. Orthologous to human WASHC5 (WASH complex subunit 5). [provided by Alliance of Genome Resources, Apr 2022]

Washc5 Products (1)

mRNA Protein Name
NM_153548.3 NP_705776.2 WASH complex subunit 5

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
acts upstream of or within lysosome organization IMP
IMP: Inferred from mutant phenotype
30061306 MGI
involved in meiotic spindle assembly IMP
IMP: Inferred from mutant phenotype
24998208 MGI
involved in oocyte maturation IMP
IMP: Inferred from mutant phenotype
24998208 MGI
involved in polar body extrusion after meiotic divisions IMP
IMP: Inferred from mutant phenotype
24998208 MGI
acts upstream of or within protein-containing complex localization IMP
IMP: Inferred from mutant phenotype
27390154 MGI
acts upstream of or within protein-containing complex organization IMP
IMP: Inferred from mutant phenotype
26572744 MGI
acts upstream of or within regulation of actin nucleation IMP
IMP: Inferred from mutant phenotype
27390154 MGI
acts upstream of or within regulation of vesicle size IMP
IMP: Inferred from mutant phenotype
27390154 MGI
Cellular Component GO Annotation Evidence References Source
part of WASH complex IDA
IDA: Inferred from direct assay
27390154 MGI
located in endosome IDA
IDA: Inferred from direct assay
20923837 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

WASH complex subunit 5

  • WASH complex subunit strumpellin

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15746 WASHC5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Washc5 NCBI NCBI:9897