2. Gene
  3. Eif4h - eukaryotic translation initiation factor 4H Gene

Eif4h - eukaryotic translation initiation factor 4H Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Ef4h; Wscr1; Wbscr1; eIF-4H; D5Ertd355e; E430026L18Rik

Gene ID: 22384 | Gene type: protein coding

About Eif4h

Summary

This gene encodes eukaryotic translation initiation factor 4H (eIF4H) that plays a critical role in the process of protein synthesis. The encoded protein is an RNA-binding protein that, in concert with Other translation initiation factors, helps unwind the 5' cap-proximal region of mRNA to prepare it for ribosomal attachment. Mice lacking the encoded protein displayed growth retardation with a significant reduction of body weight, a smaller brain volume and altered brain morphology. Behaviorally, mice lacking the encoded protein exhibit severe impairments of fear-related associative learning and memory formation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]

Eif4h Products(2)

mRNA Protein Name
NM_001312867.1 NP_001299796.1 eukaryotic translation initiation factor 4H isoform 2
NM_033561.2 NP_291039.1 eukaryotic translation initiation factor 4H isoform 1
Gene Ontology
  • Biological Process
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within developmental growth IMP
IMP: Inferred from mutant phenotype
22234171 MGI
acts upstream of or within sexual reproduction IMP
IMP: Inferred from mutant phenotype
22234171 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

eukaryotic translation initiation factor 4H

williams-Beuren syndrome chromosomal region 1 protein homolog

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS04284 EIF4H Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Eif4h NCBI NCBI:7458