2. Gene
  3. Fgd4 - FYVE, RhoGEF and PH domain containing 4 Gene

Fgd4 - FYVE, RhoGEF and PH domain containing 4 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Frabp; ZFYVE6; 9030023J02Rik; 9330209B17Rik

Gene ID: 224014 | Gene type: protein coding

About Fgd4

Summary

This gene is a member of the FYVE, RhoGEF and PH domain containing (FGD) family. The encoded protein is a Cdc42-specific guanine nucleotide exchange factor (GEF) that plays an essential role in regulating the actin Cytoskeleton and cell morphology. Disruption of the gene in mouse causes abnormal nerve development and dysmyelination. Mutations in a similar gene in human can cause Charcot-Marie-Tooth disease type 4H (CMT4H), a disorder of the peripheral nervous system. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]

Fgd4 Products(3)

mRNA Protein Name
NM_001301817.1 NP_001288746.1 FYVE, RhoGEF and PH domain-containing protein 4 isoform 1
NM_001301818.1 NP_001288747.1 FYVE, RhoGEF and PH domain-containing protein 4 isoform alpha
NM_139232.3 NP_631978.1 FYVE, RhoGEF and PH domain-containing protein 4 isoform alpha
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within lamellipodium assembly IDA
IDA: Inferred from direct assay
11527409 MGI
acts upstream of or within microspike assembly IDA
IDA: Inferred from direct assay
11527409 MGI
Cellular Component GO Annotation Evidence Reference Source
located in filopodium IDA
IDA: Inferred from direct assay
11527409 MGI
located in lamellipodium IDA
IDA: Inferred from direct assay
11527409 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

FYVE, RhoGEF and PH domain-containing protein 4

Fgd1-related F-actin-binding protein

actin filament-binding protein frabin

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS04883 FGD4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Fgd4 NCBI NCBI:121512