Poglut1 - protein O-glucosyltransferase 1 Gene

Mus musculus

Also known as Rumi; wsnp; Clp46; Ktelc1; 9630046K23Rik

Gene ID: 224143 | Gene type: protein coding

About Poglut1

Summary

This gene encodes a protein that can catalyze transfer of either UDP-glucose or UDP-xylose to epidermal growth factor (EGF) repeats, such as those found in Notch. Loss of this gene product results in embryonic lethality. Embryos have neural plate defects, heart defects, and truncations of their posterior axis. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Poglut1 Products(2)

mRNA	Protein	Name
NM_001300827.1	NP_001287756.1	protein O-glucosyltransferase 1 isoform 2
NM_172380.4	NP_759012.1	protein O-glucosyltransferase 1 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables UDP-glucosyltransferase activity	IDA IDA: Inferred from direct assay	21949356	MGI
enables UDP-xylosyltransferase activity	IDA IDA: Inferred from direct assay	21949356	MGI
enables UDP-xylosyltransferase activity	IMP IMP: Inferred from mutant phenotype	21949356	MGI
enables glucosyltransferase activity	IMP IMP: Inferred from mutant phenotype	21490058	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	26496195	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within axial mesoderm development	IMP IMP: Inferred from mutant phenotype	15755804	MGI
acts upstream of or within circulatory system development	IMP IMP: Inferred from mutant phenotype	21490058	MGI
acts upstream of or within paraxial mesoderm development	IMP IMP: Inferred from mutant phenotype	9636176	MGI
involved in positive regulation of Notch signaling pathway	IMP IMP: Inferred from mutant phenotype	26496195	MGI
acts upstream of or within protein O-linked glycosylation	IMP IMP: Inferred from mutant phenotype	21490058	MGI
involved in protein O-linked glycosylation via serine	IMP IMP: Inferred from mutant phenotype	26496195	MGI
acts upstream of or within regulation of Notch signaling pathway	IMP IMP: Inferred from mutant phenotype	21490058	MGI
involved in regulation of gastrulation	IMP IMP: Inferred from mutant phenotype	26496195	MGI
acts upstream of or within somitogenesis	IMP IMP: Inferred from mutant phenotype	9636176	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

protein O-glucosyltransferase 1

CAP10-like 46 kDa protein	KTEL (Lys-Tyr-Glu-Leu) containing 1
KTEL motif-containing protein 1	O-glucosyltransferase Rumi homolog
protein O-xylosyltransferase POGLUT1	wing-shaped neural plate protein

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-E70178	Protein O-Glucosyltransferase 1		/	Unkown
HY-RS10814	POGLUT1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Poglut1	NCBI	NCBI:56983

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