Wnt7b - wingless-type MMTV integration site family, member 7B Gene

Also Known as Wnt-7b

Species: Mus musculus

Gene Type: protein coding
Gene ID: 22422

Summary

Enables chemoattractant activity involved in axon guidance and Frizzled binding activity. Involved in nervous system development and stem cell development. Acts upstream of or within several processes, including animal organ development; blood vessel morphogenesis; and oxygen homeostasis. Located in cell surface. Is expressed in several structures, including central nervous system; early conceptus; future brain; genitourinary system; and sensory organ. Orthologous to human WNT7B (Wnt family member 7B). [provided by Alliance of Genome Resources, Apr 2022]

Wnt7b Products (3)

mRNA Protein Name
NM_001163633.1 NP_001157105.1 protein Wnt-7b isoform 3
NM_001163634.1 NP_001157106.1 protein Wnt-7b isoform 2
NM_009528.3 NP_033554.3 protein Wnt-7b isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables chemoattractant activity involved in axon guidance IDA
IDA: Inferred from direct assay
21106844 MGI
enables frizzled binding IPI
IPI: Inferred from physical interaction
15923619 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
10866835 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
18367557 MGI
involved in Wnt signaling pathway, planar cell polarity pathway IMP
IMP: Inferred from mutant phenotype
21106844 MGI
acts upstream of or within anatomical structure regression IMP
IMP: Inferred from mutant phenotype
16163358 MGI
acts upstream of or within angiogenesis IGI
IGI: Inferred from genetic interaction
19129494 MGI
acts upstream of or within angiogenesis IMP
IMP: Inferred from mutant phenotype
19129494 MGI
acts upstream of or within apoptotic process involved in blood vessel morphogenesis IMP
IMP: Inferred from mutant phenotype
16163358 MGI
acts upstream of or within canonical Wnt signaling pathway IDA
IDA: Inferred from direct assay
17804636 MGI
acts upstream of or within canonical Wnt signaling pathway IGI
IGI: Inferred from genetic interaction
15923619 MGI
acts upstream of or within canonical Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
19060336 MGI
acts upstream of cell population proliferation IMP
IMP: Inferred from mutant phenotype
19690384 MGI
involved in cell proliferation in forebrain IDA
IDA: Inferred from direct assay
12843296 MGI
acts upstream of or within cellular metabolic process IMP
IMP: Inferred from mutant phenotype
18367557 MGI
acts upstream of or within central nervous system vasculogenesis IGI
IGI: Inferred from genetic interaction
19023080 MGI
involved in chemoattraction of dopaminergic neuron axon IDA
IDA: Inferred from direct assay
21106844 MGI
acts upstream of or within chorio-allantoic fusion IMP
IMP: Inferred from mutant phenotype
11543617 MGI
acts upstream of or within developmental growth involved in morphogenesis IMP
IMP: Inferred from mutant phenotype
19060336 MGI
acts upstream of or within embryonic organ development IMP
IMP: Inferred from mutant phenotype
18367557 MGI
acts upstream of or within embryonic placenta morphogenesis IMP
IMP: Inferred from mutant phenotype
11543617 MGI
acts upstream of or within establishment or maintenance of polarity of embryonic epithelium IMP
IMP: Inferred from mutant phenotype
19060336 MGI
involved in forebrain regionalization IEP
IEP: Inferred from expression pattern
15164427 MGI
acts upstream of or within homeostatic process IMP
IMP: Inferred from mutant phenotype
18367557 MGI
acts upstream of or within in utero embryonic development IMP
IMP: Inferred from mutant phenotype
18367557 MGI
acts upstream of or within inner medullary collecting duct development IMP
IMP: Inferred from mutant phenotype
19060336 MGI
acts upstream of or within intracellular oxygen homeostasis IMP
IMP: Inferred from mutant phenotype
18367557 MGI
acts upstream of or within lobar bronchus development IMP
IMP: Inferred from mutant phenotype
18367557 MGI
acts upstream of or within lung development IMP
IMP: Inferred from mutant phenotype
18343501 MGI
acts upstream of or within lung epithelium development IMP
IMP: Inferred from mutant phenotype
18367557 MGI
acts upstream of or within lung morphogenesis IMP
IMP: Inferred from mutant phenotype
18367557 MGI
acts upstream of or within lung-associated mesenchyme development IMP
IMP: Inferred from mutant phenotype
18367557 MGI
acts upstream of or within metanephric collecting duct development IMP
IMP: Inferred from mutant phenotype
19060336 MGI
acts upstream of or within metanephric epithelium development IMP
IMP: Inferred from mutant phenotype
19060336 MGI
acts upstream of or within metanephric loop of Henle development IMP
IMP: Inferred from mutant phenotype
19060336 MGI
acts upstream of or within metanephros morphogenesis IMP
IMP: Inferred from mutant phenotype
19060336 MGI
involved in negative regulation of neurogenesis IDA
IDA: Inferred from direct assay
12843296 MGI
acts upstream of or within negative regulation of smoothened signaling pathway IMP
IMP: Inferred from mutant phenotype
10781055 MGI
acts upstream of or within odontogenesis of dentin-containing tooth IMP
IMP: Inferred from mutant phenotype
10781055 MGI
acts upstream of osteoblast differentiation IDA
IDA: Inferred from direct assay
15576404 MGI
acts upstream of or within outer medullary collecting duct development IMP
IMP: Inferred from mutant phenotype
19060336 MGI
acts upstream of or within positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
19690384 MGI
acts upstream of or within positive regulation of gene expression IMP
IMP: Inferred from mutant phenotype
19690384 MGI
acts upstream of or within positive regulation of osteoblast differentiation IDA
IDA: Inferred from direct assay
15576404 MGI
acts upstream of or within renal inner medulla development IMP
IMP: Inferred from mutant phenotype
19060336 MGI
acts upstream of or within renal outer medulla development IMP
IMP: Inferred from mutant phenotype
19060336 MGI
acts upstream of or within smooth muscle cell differentiation IMP
IMP: Inferred from mutant phenotype
19690384 MGI
involved in stem cell development IDA
IDA: Inferred from direct assay
12843296 MGI
acts upstream of or within synapse organization IGI
IGI: Inferred from genetic interaction
16818724 MGI
acts upstream of or within trachea cartilage morphogenesis IMP
IMP: Inferred from mutant phenotype
18367557 MGI
acts upstream of or within vasculature development IMP
IMP: Inferred from mutant phenotype
16163358 MGI
Cellular Component GO Annotation Evidence References Source
located in cell surface IDA
IDA: Inferred from direct assay
8167409 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein Wnt-7b

  • wingless-related MMTV integration site 7B

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15841 WNT7B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21808 Wnt7b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28324 Wnt7b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Wnt7b NCBI NCBI:7477