Xirp1 - xin actin-binding repeat containing 1 Gene

Mus musculus

Also known as Cmya1

Gene ID: 22437 | Gene type: protein coding

About Xirp1

Summary

Predicted to enable actin filament binding activity and filamin binding activity. Acts upstream of or within several processes, including Notch signaling pathway; muscle cell development; and negative regulation of cell population proliferation. Located in adherens junction and fascia adherens. Is expressed in several structures, including heart; musculature; and tail somite. Used to study hypertrophic cardiomyopathy. Orthologous to human XIRP1 (xin actin binding repeat containing 1). [provided by Alliance of Genome Resources, Apr 2022]

Xirp1 Products(2)

mRNA	Protein	Name
NM_001406404.1	NP_001393333.1	xin actin-binding repeat-containing protein 1
NM_011724.5	NP_035854.4	xin actin-binding repeat-containing protein 1

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within Notch signaling pathway	IDA IDA: Inferred from direct assay	23117660	MGI
acts upstream of or within cardiac muscle cell development	IMP IMP: Inferred from mutant phenotype	17766470	MGI
involved in myoblast differentiation involved in skeletal muscle regeneration	IMP IMP: Inferred from mutant phenotype	25582411	MGI
acts upstream of or within negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	17855775	MGI
involved in protein localization	IMP IMP: Inferred from mutant phenotype	23296090	MGI
acts upstream of or within regulation of membrane potential	IMP IMP: Inferred from mutant phenotype	17766470	MGI
acts upstream of or within sarcomere organization	IMP IMP: Inferred from mutant phenotype	17766470	MGI
involved in satellite cell activation involved in skeletal muscle regeneration	IMP IMP: Inferred from mutant phenotype	25582411	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in adherens junction	IDA IDA: Inferred from direct assay	12203715	MGI
located in fascia adherens	IDA IDA: Inferred from direct assay	10021346	MGI
located in intercalated disc	IDA IDA: Inferred from direct assay	17766470	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

xin actin-binding repeat-containing protein 1

Xin alpha	cardiomyopathy associated 1
cardiomyopathy-associated protein 1	mXin alpha

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15876	XIRP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Xirp1	NCBI	NCBI:165904

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