Tmem63b - transmembrane protein 63b Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 224807

Summary

Enables calcium activated cation channel activity; mechanosensitive ion channel activity; and osmolarity-sensing cation channel activity. Predicted to act upstream of or within ion transport. Located in plasma membrane. Is expressed in jaw bone; nervous system; and sensory organ. Orthologous to human TMEM63B (transmembrane protein 63B). [provided by Alliance of Genome Resources, Apr 2022]

Tmem63b Products (6)

mRNA Protein Name
NM_001413622.1 NP_001400551.1 CSC1-like protein 2 isoform 1
NM_001413623.1 NP_001400552.1 CSC1-like protein 2 isoform 1
NM_001413624.1 NP_001400553.1 CSC1-like protein 2 isoform 2
NM_001413625.1 NP_001400554.1 CSC1-like protein 2 isoform 2
NM_001413626.1 NP_001400555.1 CSC1-like protein 2 isoform 3
NM_198167.4 NP_937810.2 CSC1-like protein 2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables calcium-activated cation channel activity IDA
IDA: Inferred from direct assay
31243992 MGI
enables mechanosensitive monoatomic ion channel activity IDA
IDA: Inferred from direct assay
30382938 MGI
enables osmolarity-sensing monoatomic cation channel activity IDA
IDA: Inferred from direct assay
27045885 MGI
Biological Process GO Annotation Evidence References Source
involved in sensory perception of sound IMP
IMP: Inferred from mutant phenotype
32375046 MGI
involved in surfactant secretion IMP
IMP: Inferred from mutant phenotype
38127458 MGI
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
27045885 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

CSC1-like protein 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14733 TMEM63B Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tmem63b NCBI NCBI:55362