Ubr2 - ubiquitin protein ligase E3 component n-recognin 2 Gene

Mus musculus

Also known as mKIAA0349; 9930021A08Rik; E130209G04Rik

Gene ID: 224826 | Gene type: protein coding

About Ubr2

Summary

Enables ubiquitin protein Ligase activity. Involved in several processes, including histone H2A ubiquitination; male gamete generation; and negative regulation of transposition. Acts upstream of or within male meiosis I and ubiquitin-dependent protein catabolic process. Part of ubiquitin Ligase complex. Colocalizes with chromatin. Is expressed in several structures, including alimentary system; endocrine gland; eye; genitourinary system; and trachea. Orthologous to human UBR2 (ubiquitin protein Ligase E3 component n-recognin 2). [provided by Alliance of Genome Resources, Apr 2022]

Ubr2 Products(2)

mRNA	Protein	Name
NM_001177374.2	NP_001170845.1	E3 ubiquitin-protein ligase UBR2 isoform 2
NM_146078.4	NP_666190.2	E3 ubiquitin-protein ligase UBR2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables histone H2A ubiquitin ligase activity	IDA IDA: Inferred from direct assay	20080676	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	11689692	MGI
enables ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	14585983	MGI
enables ubiquitin protein ligase activity	IGI IGI: Inferred from genetic interaction	11689692	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in heterochromatin formation	IDA IDA: Inferred from direct assay	20080676	MGI
acts upstream of or within male meiosis I	IMP IMP: Inferred from mutant phenotype	14585983	MGI
involved in male meiotic nuclear division	IMP IMP: Inferred from mutant phenotype	28708824	MGI
involved in reciprocal meiotic recombination	IMP IMP: Inferred from mutant phenotype	28708824	MGI
involved in retrotransposon silencing	IMP IMP: Inferred from mutant phenotype	28806172	MGI
acts upstream of or within spermatogenesis	IMP IMP: Inferred from mutant phenotype	14585983	MGI
involved in spermatogenesis	IMP IMP: Inferred from mutant phenotype	28708824	MGI
acts upstream of or within ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	14585983	MGI
involved in ubiquitin-dependent protein catabolic process via the N-end rule pathway	IDA IDA: Inferred from direct assay	19008229	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in chromatin	IDA IDA: Inferred from direct assay	20080676	MGI
part of ubiquitin ligase complex	IGI IGI: Inferred from genetic interaction	11689692	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

E3 ubiquitin-protein ligase UBR2

N-recognin-2	RING-type E3 ubiquitin transferase UBR2
ubiquitin ligase E3 alpha-II	ubiquitin-protein ligase E3-alpha-2
ubiquitin-protein ligase E3-alpha-II

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15387	UBR2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ubr2	NCBI	NCBI:23304

Name
Email *

	Sorry, but the email address you supplied was invalid.