Ubr2 - ubiquitin protein ligase E3 component n-recognin 2 Gene

Also Known as mKIAA0349; 9930021A08Rik; E130209G04Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 224826

Summary

Enables ubiquitin protein Ligase activity. Involved in several processes, including histone H2A ubiquitination; male gamete generation; and negative regulation of transposition. Acts upstream of or within male meiosis I and ubiquitin-dependent protein catabolic process. Part of ubiquitin Ligase complex. Colocalizes with chromatin. Is expressed in several structures, including alimentary system; endocrine gland; eye; genitourinary system; and trachea. Orthologous to human UBR2 (ubiquitin protein Ligase E3 component n-recognin 2). [provided by Alliance of Genome Resources, Apr 2022]

Ubr2 Products (2)

mRNA Protein Name
NM_001177374.2 NP_001170845.1 E3 ubiquitin-protein ligase UBR2 isoform 2
NM_146078.4 NP_666190.2 E3 ubiquitin-protein ligase UBR2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables histone H2A ubiquitin ligase activity IDA
IDA: Inferred from direct assay
20080676 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
11689692 MGI
enables ubiquitin protein ligase activity IDA
IDA: Inferred from direct assay
14585983 MGI
enables ubiquitin protein ligase activity IGI
IGI: Inferred from genetic interaction
11689692 MGI
Biological Process GO Annotation Evidence References Source
involved in heterochromatin formation IDA
IDA: Inferred from direct assay
20080676 MGI
acts upstream of or within male meiosis I IMP
IMP: Inferred from mutant phenotype
14585983 MGI
involved in male meiotic nuclear division IMP
IMP: Inferred from mutant phenotype
28708824 MGI
involved in reciprocal meiotic recombination IMP
IMP: Inferred from mutant phenotype
28708824 MGI
involved in retrotransposon silencing IMP
IMP: Inferred from mutant phenotype
28806172 MGI
acts upstream of or within spermatogenesis IMP
IMP: Inferred from mutant phenotype
14585983 MGI
involved in spermatogenesis IMP
IMP: Inferred from mutant phenotype
28708824 MGI
acts upstream of or within ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
14585983 MGI
involved in ubiquitin-dependent protein catabolic process via the N-end rule pathway IDA
IDA: Inferred from direct assay
19008229 MGI
Cellular Component GO Annotation Evidence References Source
located in chromatin IDA
IDA: Inferred from direct assay
20080676 MGI
part of ubiquitin ligase complex IGI
IGI: Inferred from genetic interaction
11689692 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase UBR2

  • N-recognin-2

  • RING-type E3 ubiquitin transferase UBR2

  • ubiquitin ligase E3 alpha-II

  • ubiquitin-protein ligase E3-alpha-2

  • ubiquitin-protein ligase E3-alpha-II

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15387 UBR2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ubr2 NCBI NCBI:23304