Treml4 - triggering receptor expressed on myeloid cells-like 4 Gene

Also Known as TLT4; IDCP1; TLT-4; Treml3; 5031403H21Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 224840

Summary

Predicted to enable signaling receptor activity. Involved in positive regulation of defense response to virus by host; positive regulation of Toll-like Receptor signaling pathway; and protein localization. Acts upstream of or within T cell antigen processing and presentation and phagocytosis, engulfment. Located in endoplasmic reticulum. Colocalizes with endosome membrane and lysosomal membrane. Orthologous to human TREML4 (triggering receptor expressed on myeloid cells like 4). [provided by Alliance of Genome Resources, Apr 2022]

Treml4 Products (4)

mRNA	Protein	Name
NM_001033922.2	NP_001029094.1	trem-like transcript 4 protein isoform 1 precursor
NM_001163795.1	NP_001157267.1	trem-like transcript 4 protein isoform 3 precursor
NM_001163796.1	NP_001157268.1	trem-like transcript 4 protein isoform 4 precursor
NM_172623.2	NP_766211.2	trem-like transcript 4 protein isoform 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	19155473	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within T cell antigen processing and presentation	IMP IMP: Inferred from mutant phenotype	22210914	MGI
acts upstream of or within phagocytosis, engulfment	IDA IDA: Inferred from direct assay	19155473	MGI
involved in positive regulation of defense response to virus by host	IMP IMP: Inferred from mutant phenotype	25848864	MGI
involved in positive regulation of toll-like receptor 13 signaling pathway	IMP IMP: Inferred from mutant phenotype	25848864	MGI
involved in positive regulation of toll-like receptor 7 signaling pathway	IMP IMP: Inferred from mutant phenotype	25848864	MGI
involved in positive regulation of toll-like receptor 9 signaling pathway	IMP IMP: Inferred from mutant phenotype	25848864	MGI
involved in protein localization	IMP IMP: Inferred from mutant phenotype	25848864	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	25848864	MGI
colocalizes with endosome membrane	IDA IDA: Inferred from direct assay	25848864	MGI
colocalizes with lysosomal membrane	IDA IDA: Inferred from direct assay	25848864	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
trem-like transcript 4 protein	IG-like domain containing protein IDCP1c triggering receptor expressed on myeloid cells-like 3 triggering receptor expressed on myeloid cells-like 3b triggering receptor expressed on myeloid cells-like protein 3 triggering receptor expressed on myeloi

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15006	TREML4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Treml4	NCBI	NCBI:285852