Svil - supervillin Gene

Also Known as B430302E16Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 225115

Summary

Predicted to enable actin filament binding activity and phosphatidylinositol-4,5-bisphosphate binding activity. Predicted to be involved in several processes, including actin filament severing; actin polymerization or depolymerization; and barbed-end actin filament capping. Predicted to be located in several cellular components, including costamere; cytosol; and nucleus. Predicted to be active in actin Cytoskeleton and cytoplasm. Is expressed in several structures, including exoccipital bone; gut; meninges; pharyngo-tympanic tube; and skin. Human ortholog(s) of this gene implicated in myofibrillar myopathy 10. Orthologous to human SVIL (supervillin). [provided by Alliance of Genome Resources, Apr 2022]

Svil Products (8)

mRNA Protein Name
NM_001347449.1 NP_001334378.1 supervillin isoform b
NM_001405277.1 NP_001392206.1 supervillin isoform c
NM_001405278.1 NP_001392207.1 supervillin isoform d
NM_001405280.1 NP_001392209.1 supervillin isoform d
NM_001405281.1 NP_001392210.1 supervillin isoform d
NM_001405282.1 NP_001392211.1 supervillin isoform a
NM_001405290.1 NP_001392219.1 supervillin isoform d
NM_153153.4 NP_694793.1 supervillin isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables actin filament binding IDA
IDA: Inferred from direct assay
12711699 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within muscle cell differentiation IDA
IDA: Inferred from direct assay
12711699 MGI
Cellular Component GO Annotation Evidence References Source
located in cell periphery IDA
IDA: Inferred from direct assay
12711699 MGI
located in costamere IDA
IDA: Inferred from direct assay
12711699 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
12711699 MGI
located in focal adhesion IDA
IDA: Inferred from direct assay
12711699 MGI
located in nucleoplasm IDA
IDA: Inferred from direct assay
12711699 MGI
located in sarcolemma IDA
IDA: Inferred from direct assay
12711699 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

supervillin

  • archvillin

  • p205/p250

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14059 SVIL Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Svil NCBI NCBI:6840