Myrf - myelin regulatory factor Gene

Also Known as Mrf; Gm98; Gm1804; 6030439E18

Species: Mus musculus

Gene Type: protein coding
Gene ID: 225908

Summary

Enables DNA binding activity and DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in several processes, including central nervous system myelin maintenance; positive regulation of myelination; and regulation of transcription, DNA-templated. Located in endoplasmic reticulum membrane and nucleus. Is expressed in pigmented retinal epithelium; spinal cord; and spinal cord marginal layer. Orthologous to human MYRF (myelin regulatory factor). [provided by Alliance of Genome Resources, Apr 2022]

Myrf Products (2)

mRNA Protein Name
NM_001033481.2 NP_001028653.1 myelin regulatory factor isoform 1
NM_001404113.1 NP_001391042.1 myelin regulatory factor isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
24204311 MGI
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
24204311 MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
31828317 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
30249802 MGI
Biological Process GO Annotation Evidence References Source
involved in central nervous system myelin maintenance IMP
IMP: Inferred from mutant phenotype
22956843 MGI
involved in central nervous system myelination IMP
IMP: Inferred from mutant phenotype
19596243 MGI
involved in oligodendrocyte development IDA
IDA: Inferred from direct assay
31828317 MGI
involved in oligodendrocyte development IMP
IMP: Inferred from mutant phenotype
19596243 MGI
involved in oligodendrocyte differentiation IMP
IMP: Inferred from mutant phenotype
22956843 MGI
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
19596243 MGI
involved in positive regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
22956843 MGI
involved in positive regulation of myelination IMP
IMP: Inferred from mutant phenotype
19596243 MGI
involved in protein autoprocessing IDA
IDA: Inferred from direct assay
30249802 MGI
involved in regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
31828317 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
30249802 MGI
located in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
30249802 MGI
located in nucleus IDA
IDA: Inferred from direct assay
19596243 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

myelin regulatory factor

  • myelin gene regulatory factor

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08969 MYRF Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18955 Myrf Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25445 Myrf Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Myrf NCBI NCBI:745