Ercc5 - excision repair cross-complementing rodent repair deficiency, complementation group 5 Gene

Also Known as Xpg

Species: Mus musculus

Gene Type: protein coding
Gene ID: 22592

Summary

Predicted to enable several functions, including DNA binding activity; RNA polymerase II complex binding activity; and protein homodimerization activity. Acts upstream of or within UV protection; determination of adult lifespan; and nucleotide-excision repair. Predicted to be located in chromosome. Predicted to be part of DNA replication factor A complex and nucleotide-excision repair complex. Predicted to be active in nucleus. Is expressed in central nervous system; genitourinary system; and retina. Used to study xeroderma pigmentosum group G. Human ortholog(s) of this gene implicated in cerebrooculofacioskeletal syndrome 3; melanoma; and xeroderma pigmentosum group G. Orthologous to human ERCC5 (ERCC excision repair 5, Endonuclease). [provided by Alliance of Genome Resources, Apr 2022]

Ercc5 Products (1)

mRNA Protein Name
NM_011729.2 NP_035859.2 DNA excision repair protein ERCC-5

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
acts upstream of or within DNA repair IMP
IMP: Inferred from mutant phenotype
15082767 MGI
acts upstream of or within UV protection IDA
IDA: Inferred from direct assay
8703115 MGI
acts upstream of or within UV protection IMP
IMP: Inferred from mutant phenotype
7510366 MGI
acts upstream of or within determination of adult lifespan IMP
IMP: Inferred from mutant phenotype
15082767 MGI
acts upstream of or within multicellular organism growth IMP
IMP: Inferred from mutant phenotype
10022922 MGI
acts upstream of or within nucleotide-excision repair IMP
IMP: Inferred from mutant phenotype
10022922 MGI
acts upstream of or within response to UV IMP
IMP: Inferred from mutant phenotype
15082767 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

DNA excision repair protein ERCC-5

DNA repair protein complementing XP-G cells homolog

  • xeroderma pigmentosum group G-complementing protein homolog

  • xeroderma pigmentosum, complementation group G

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04482 ERCC5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ercc5 NCBI NCBI:2073