Lzts2 - leucine zipper, putative tumor suppressor 2 Gene

Also Known as LAPSER1; mKIAA1813

Species: Mus musculus

Gene Type: protein coding

Gene ID: 226154

Summary

Acts upstream of or within several processes, including negative regulation of canonical Wnt signaling pathway; negative regulation of protein localization to nucleus; and tube morphogenesis. Located in cytoplasm. Is expressed in several structures, including 1st branchial arch mandibular component; adrenal gland; forelimb bud; future brain; and genitourinary system. Used to study urinary system disease. Orthologous to human LZTS2 (leucine zipper tumor suppressor 2). [provided by Alliance of Genome Resources, Apr 2022]

Lzts2 Products (3)

mRNA	Protein	Name
NM_001130525.1	NP_001123997.1	leucine zipper putative tumor suppressor 2
NM_001130526.1	NP_001123998.1	leucine zipper putative tumor suppressor 2
NM_145503.2	NP_663478.2	leucine zipper putative tumor suppressor 2

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within Wnt signaling pathway	IGI IGI: Inferred from genetic interaction	23275340	MGI
acts upstream of Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	21949185	MGI
acts upstream of fibroblast proliferation	IMP IMP: Inferred from mutant phenotype	23275340	MGI
acts upstream of or within kidney development	IMP IMP: Inferred from mutant phenotype	21949185	MGI
acts upstream of or within negative regulation of Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	21949185	MGI
acts upstream of or within negative regulation of canonical Wnt signaling pathway	IGI IGI: Inferred from genetic interaction	23275340	MGI
acts upstream of or within negative regulation of fibroblast proliferation	IMP IMP: Inferred from mutant phenotype	23275340	MGI
acts upstream of or within negative regulation of protein localization to nucleus	IMP IMP: Inferred from mutant phenotype	23275340	MGI
acts upstream of or within primary ureteric bud growth	IMP IMP: Inferred from mutant phenotype	21949185	MGI
acts upstream of or within ureter morphogenesis	IMP IMP: Inferred from mutant phenotype	21949185	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	23275340	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
leucine zipper putative tumor suppressor 2	protein LAPSER1 putative tumor suppressor LAPSER1

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07935	LZTS2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Lzts2	NCBI	NCBI:84445