2. Gene
  3. Rab3gap1 - RAB3 GTPase activating protein subunit 1 Gene

Rab3gap1 - RAB3 GTPase activating protein subunit 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as p130; Rab3gap; 1700003B17Rik; 4732493F09Rik; rab3-GAP p130

Gene ID: 226407 | Gene type: protein coding

About Rab3gap1

Summary

Predicted to enable GTPase activator activity and small GTPase binding activity. Predicted to contribute to guanyl-nucleotide exchange factor activity. Involved in several processes, including excitatory postsynaptic potential; modulation of chemical synaptic transmission; and positive regulation of GTPase activity. Predicted to be located in several cellular components, including endoplasmic reticulum tubular network; excitatory synapse; and lipid droplet. Predicted to be part of protein-containing complex. Is expressed in several structures, including brain and neural retina. Human ortholog(s) of this gene implicated in Warburg micro syndrome 1. Orthologous to human RAB3GAP1 (RAB3 GTPase activating protein catalytic subunit 1). [provided by Alliance of Genome Resources, Apr 2022]

Rab3gap1 Products(2)

mRNA Protein Name
NM_001402313.1 NP_001389242.1 rab3 GTPase-activating protein catalytic subunit isoform 1
NM_178690.5 NP_848805.2 rab3 GTPase-activating protein catalytic subunit isoform 2
Gene Ontology
  • Biological Process
Biological Process GO Annotation Evidence Reference Source
involved in excitatory postsynaptic potential IMP
IMP: Inferred from mutant phenotype
16782817 MGI
involved in positive regulation of GTPase activity IMP
IMP: Inferred from mutant phenotype
16782817 MGI
involved in positive regulation of gene expression IDA
IDA: Inferred from direct assay
16782817 MGI
involved in positive regulation of glutamate neurotransmitter secretion in response to membrane depolarization IMP
IMP: Inferred from mutant phenotype
16782817 MGI
involved in regulation of calcium ion-dependent exocytosis of neurotransmitter IMP
IMP: Inferred from mutant phenotype
16782817 MGI
involved in regulation of short-term neuronal synaptic plasticity IMP
IMP: Inferred from mutant phenotype
16782817 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

rab3 GTPase-activating protein catalytic subunit

RAB3 GTPase-activating protein 130 kDa subunit

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS11559 RAB3GAP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rab3gap1 NCBI NCBI:22930