Zfp57 - zinc finger protein 57 Gene

Also Known as G19; Zfp-57

Species: Mus musculus

Gene Type: protein coding
Gene ID: 22715

Summary

Enables chromatin binding activity and double-stranded methylated DNA binding activity. Involved in genetic imprinting; maintenance of DNA methylation; and regulation of genetic imprinting. Acts upstream of or within DNA methylation involved in embryo development; genetic imprinting; and negative regulation of transcription by RNA polymerase II. Located in heterochromatin and nucleus. Is expressed in several structures, including early conceptus; genitourinary system; liver; nervous system; and retina. Orthologous to human ZFP57 (ZFP57 Zinc Finger Protein). [provided by Alliance of Genome Resources, Apr 2022]

Zfp57 Products (3)

mRNA Protein Name
NM_001013745.2 NP_001013767.1 zinc finger protein 57 isoform 1
NM_001168501.1 NP_001161973.1 zinc finger protein 57 isoform 1
NM_001168502.1 NP_001161974.1 zinc finger protein 57 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
22495301 MGI
enables chromatin binding IDA
IDA: Inferred from direct assay
30602440 MGI
enables double-stranded methylated DNA binding IDA
IDA: Inferred from direct assay
30602440 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
18854139 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within autosome genomic imprinting IMP
IMP: Inferred from mutant phenotype
33500348 MGI
involved in autosome genomic imprinting IMP
IMP: Inferred from mutant phenotype
18854139 MGI
involved in epigenetic programing of female pronucleus IGI
IGI: Inferred from genetic interaction
30602440 MGI
acts upstream of or within epigenetic programming in the zygotic pronuclei IMP
IMP: Inferred from mutant phenotype
33500348 MGI
acts upstream of or within genomic imprinting IMP
IMP: Inferred from mutant phenotype
33500348 MGI
involved in negative regulation of gene expression via chromosomal CpG island methylation IGI
IGI: Inferred from genetic interaction
30602440 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
15070898 MGI
Cellular Component GO Annotation Evidence References Source
located in heterochromatin IDA
IDA: Inferred from direct assay
15070898 MGI
located in nucleus IDA
IDA: Inferred from direct assay
8120052 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

zinc finger protein 57

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS16044 ZFP57 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Zfp57 NCBI NCBI:346171