Dclre1c - DNA cross-link repair 1C Gene

Also Known as Art; Snm1l; 9930121L06Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 227525

Summary

This gene encodes a member of the SNM1 family of nucleases and is involved in V(D)J recombination and DNA repair. This protein has single-strand-specific 5'-3' exonuclease activity; it also exhibits Endonuclease activity on 5' and 3' overhangs and hairpins. The protein also functions in the regulation of the cell cycle in response to DNA damage. Homozygous knockout mice for this gene exhibit severe combined immunodeficiency with sensitivity to ionizing radiation. Mutations in this gene in humans can cause Athabascan-type severe combined immunodeficiency (SCIDA) and Omenn syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2014]

Dclre1c Products (7)

mRNA Protein Name
NM_001110214.1 NP_001103684.1 protein artemis isoform 3
NM_001302674.1 NP_001289603.1 protein artemis isoform 4
NM_001302684.1 NP_001289613.1 protein artemis isoform 5
NM_001362903.1 NP_001349832.1 protein artemis isoform 6
NM_001362904.1 NP_001349833.1 protein artemis isoform 7
NM_146114.3 NP_666226.2 protein artemis isoform 1
NM_175683.4 NP_783614.1 protein artemis isoform 2

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
acts upstream of or within B cell differentiation IMP
IMP: Inferred from mutant phenotype
12504013 MGI
acts upstream of or within DNA recombination IMP
IMP: Inferred from mutant phenotype
12504013 MGI
acts upstream of or within V(D)J recombination IMP
IMP: Inferred from mutant phenotype
23836881 MGI
acts upstream of or within chromosome organization IMP
IMP: Inferred from mutant phenotype
12504013 MGI
acts upstream of or within double-strand break repair IMP
IMP: Inferred from mutant phenotype
12615897 MGI
acts upstream of or within response to ionizing radiation IMP
IMP: Inferred from mutant phenotype
12504013 MGI
acts upstream of or within telomere maintenance IMP
IMP: Inferred from mutant phenotype
12615897 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein artemis

  • DNA cross-link repair 1A, PSO2 homolog

  • DNA cross-link repair 1C protein

  • DNA cross-link repair 1C, PSO2 homolog

  • SNM1-like protein

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03582 DCLRE1C Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dclre1c NCBI NCBI:64421