Zfpm2 - zinc finger protein, multitype 2 Gene

Also Known as FOG2; FOG-2; B330005D23Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 22762

Summary

Enables transcription corepressor activity. Involved in several processes, including negative regulation of female gonad development; positive regulation of cardiac muscle cell proliferation; and positive regulation of male gonad development. Acts upstream of or within several processes, including animal organ development; regulation of transcription by RNA polymerase II; and vasculogenesis. Located in cytoplasm and nucleus. Is expressed in several structures, including brain; heart; reproductive system; trigeminal ganglion; and urinary system. Used to study congenital diaphragmatic hernia; tetralogy of Fallot; and tricuspid atresia. Human ortholog(s) of this gene implicated in 46,XY sex reversal 9; myelodysplastic syndrome; and tetralogy of Fallot. Orthologous to human ZFPM2 (Zinc Finger Protein, FOG family member 2). [provided by Alliance of Genome Resources, Apr 2022]

Zfpm2 Products (2)

mRNA Protein Name
NM_001356998.1 NP_001343927.1 zinc finger protein ZFPM2 isoform 2
NM_011766.5 NP_035896.1 zinc finger protein ZFPM2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
20705609 MGI
enables transcription corepressor activity IDA
IDA: Inferred from direct assay
9927675 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cardiac muscle tissue development IMP
IMP: Inferred from mutant phenotype
16103912 MGI
acts upstream of or within embryonic organ development IMP
IMP: Inferred from mutant phenotype
16103912 MGI
involved in fat cell differentiation IMP
IMP: Inferred from mutant phenotype
20705609 MGI
acts upstream of or within heart development IDA
IDA: Inferred from direct assay
10892744 MGI
acts upstream of or within heart development IMP
IMP: Inferred from mutant phenotype
10888889 MGI
acts upstream of or within in utero embryonic development IMP
IMP: Inferred from mutant phenotype
16103912 MGI
acts upstream of or within lung development IMP
IMP: Inferred from mutant phenotype
16103912 MGI
involved in negative regulation of fat cell differentiation IMP
IMP: Inferred from mutant phenotype
20705609 MGI
involved in negative regulation of female gonad development IMP
IMP: Inferred from mutant phenotype
19301398 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
9927675 MGI
involved in positive regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
19301398 MGI
involved in positive regulation of cardiac muscle cell proliferation IGI
IGI: Inferred from genetic interaction
22267003 MGI
involved in positive regulation of male gonad development IMP
IMP: Inferred from mutant phenotype
19301398 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
15766748 MGI
acts upstream of or within vasculogenesis IDA
IDA: Inferred from direct assay
10892744 MGI
acts upstream of or within vasculogenesis IMP
IMP: Inferred from mutant phenotype
16103912 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
12213678 MGI
located in male germ cell nucleus IDA
IDA: Inferred from direct assay
12213678 MGI
located in nucleus IDA
IDA: Inferred from direct assay
9927675 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

zinc finger protein ZFPM2

  • Friend of GATA 2

  • friend of GATA protein 2

  • friend of GATA-1 2

  • friend of GATA-2

  • mFOG-2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS16049 ZFPM2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Zfpm2 NCBI NCBI:23414