Paxx - non-homologous end joining factor Gene

Also Known as D930050G13Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 227622

Summary

Predicted to enable DNA Polymerase binding activity; molecular adaptor activity; and protein homodimerization activity. Involved in double-strand break repair via nonhomologous end joining. Predicted to be located in nucleoplasm. Predicted to be part of Ku70:Ku80 complex and nonhomologous end joining complex. Predicted to be active in nucleus and site of double-strand break. Is expressed in brain; lung; and thymus. Orthologous to human PAXX (PAXX non-homologous end joining factor). [provided by Alliance of Genome Resources, Apr 2022]

Paxx Products (1)

mRNA Protein Name
NM_153557.2 NP_705785.1 protein PAXX

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in double-strand break repair via nonhomologous end joining IMP
IMP: Inferred from mutant phenotype
27798842 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein PAXX

  • paralog of XRCC4 and XLF

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10099 PAXX Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Paxx NCBI NCBI:286257