Sohlh1 - spermatogenesis and oogenesis specific basic helix-loop-helix 1 Gene

Also Known as Gm110; Nohlh

Species: Mus musculus

Gene Type: protein coding

Gene ID: 227631

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and protein dimerization activity. Involved in oocyte differentiation; positive regulation of transcription by RNA polymerase II; and spermatogenesis. Acts upstream of or within oogenesis; ovarian follicle development; and positive regulation of transcription, DNA-templated. Located in cytoplasm and nucleus. Is expressed in gonad and hindlimb long bone. Human ortholog(s) of this gene implicated in ovarian dysgenesis 5 and spermatogenic failure 32. Orthologous to human SOHLH1 (spermatogenesis and oogenesis specific basic helix-loop-helix 1). [provided by Alliance of Genome Resources, Apr 2022]

Sohlh1 Products (2)

mRNA	Protein	Name
NM_001001714.2	NP_001001714.1	spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 1 isoform 1
NM_001413658.1	NP_001400587.1	spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 1 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	22328502	MGI
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	16690745	MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	22328502	MGI
enables identical protein binding	IPI IPI: Inferred from physical interaction	22056784	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	22056784	MGI
enables protein heterodimerization activity	IDA IDA: Inferred from direct assay	22056784	MGI
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	22056784	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in cell differentiation	IDA IDA: Inferred from direct assay	22056784	MGI
acts upstream of or within cell differentiation	IMP IMP: Inferred from mutant phenotype	16564520	MGI
involved in oocyte differentiation	IDA IDA: Inferred from direct assay	28504655	MGI
acts upstream of or within oogenesis	IMP IMP: Inferred from mutant phenotype	16690745	MGI
acts upstream of or within ovarian follicle development	IMP IMP: Inferred from mutant phenotype	16690745	MGI
acts upstream of or within positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	16690745	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	22328502	MGI
acts upstream of or within regulation of gene expression	IMP IMP: Inferred from mutant phenotype	18753606	MGI
involved in spermatogenesis	IDA IDA: Inferred from direct assay	22056784	MGI
acts upstream of or within spermatogenesis	IMP IMP: Inferred from mutant phenotype	16564520	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	16690745	MGI
located in male germ cell nucleus	IDA IDA: Inferred from direct assay	16564520	MGI
located in nucleus	IDA IDA: Inferred from direct assay	16690745	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 1	helix-loop-helix protein NOHLH

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13564	SOHLH1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Sohlh1	NCBI	NCBI:402381