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Zic3 - zinc finger protein of the cerebellum 3 Gene

Also Known as Bn; Ka

Species: Mus musculus

Gene Type: protein coding

Gene ID: 22773

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in determination of left/right asymmetry in nervous system and positive regulation of transcription by RNA polymerase II. Acts upstream of or within anterior/posterior pattern specification and heart looping. Located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; egg cylinder; embryo ectoderm; embryo mesenchyme; and visual system. Used to study Goldenhar syndrome and visceral heterotaxy. Human ortholog(s) of this gene implicated in X-linked VACTERL association; situs inversus; and visceral heterotaxy. Orthologous to human ZIC3 (Zic family member 3). [provided by Alliance of Genome Resources, Apr 2022]

Zic3 Products (1)

mRNA	Protein	Name
NM_009575.2	NP_033601.2	zinc finger protein ZIC 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	11053430	MGI
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	11053430	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	11053430	MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	18298960	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	15207726	MGI
enables transcription coactivator activity	IMP IMP: Inferred from mutant phenotype	17468179	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within anterior/posterior pattern specification	IGI IGI: Inferred from genetic interaction	16496285	MGI
involved in atrial cardiac muscle tissue development	IMP IMP: Inferred from mutant phenotype	17468179	MGI
involved in axial mesoderm development	IGI IGI: Inferred from genetic interaction	17490632	MGI
involved in cell cycle	IGI IGI: Inferred from genetic interaction	17507568	MGI
involved in central nervous system segmentation	IGI IGI: Inferred from genetic interaction	17490632	MGI
involved in cranial skeletal system development	IMP IMP: Inferred from mutant phenotype	17127413	MGI
involved in determination of left/right asymmetry in nervous system	IMP IMP: Inferred from mutant phenotype	11959836	MGI
acts upstream of or within determination of left/right symmetry	IGI IGI: Inferred from genetic interaction	16496285	MGI
acts upstream of or within determination of left/right symmetry	IMP IMP: Inferred from mutant phenotype	15384171	MGI
involved in embryonic pattern specification	IMP IMP: Inferred from mutant phenotype	16397896	MGI
involved in face development	IMP IMP: Inferred from mutant phenotype	17127413	MGI
involved in forebrain development	IGI IGI: Inferred from genetic interaction	17507568	MGI
involved in gastrulation	IMP IMP: Inferred from mutant phenotype	16397896	MGI
involved in gene expression	IGI IGI: Inferred from genetic interaction	17490632	MGI
involved in gene expression	IMP IMP: Inferred from mutant phenotype	17267691	MGI
involved in germ-line stem cell population maintenance	IMP IMP: Inferred from mutant phenotype	32868762	MGI
involved in heart development	IMP IMP: Inferred from mutant phenotype	17127413	MGI
acts upstream of or within heart looping	IGI IGI: Inferred from genetic interaction	16496285	MGI
acts upstream of or within heart looping	IMP IMP: Inferred from mutant phenotype	15384171	MGI
involved in hippocampus development	IGI IGI: Inferred from genetic interaction	17507568	MGI
involved in left/right axis specification	IMP IMP: Inferred from mutant phenotype	17127413	MGI
involved in left/right pattern formation	IMP IMP: Inferred from mutant phenotype	23184148	MGI
involved in limb morphogenesis	IGI IGI: Inferred from genetic interaction	22234993	MGI
involved in mRNA transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	32868762	MGI
involved in maintenance of cell number	IGI IGI: Inferred from genetic interaction	17507568	MGI
involved in mesoderm development	IMP IMP: Inferred from mutant phenotype	16397896	MGI
involved in neural plate development	IGI IGI: Inferred from genetic interaction	17490632	MGI
involved in neuron differentiation	IMP IMP: Inferred from mutant phenotype	17507568	MGI
involved in olfactory bulb development	IDA IDA: Inferred from direct assay	28814342	MGI
involved in olfactory bulb development	IGI IGI: Inferred from genetic interaction	17507568	MGI
involved in outer ear morphogenesis	IMP IMP: Inferred from mutant phenotype	17127413	MGI
involved in paraxial mesoderm development	IGI IGI: Inferred from genetic interaction	17490632	MGI
acts upstream of or within pattern specification process	IMP IMP: Inferred from mutant phenotype	11959836	MGI
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	11053430	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16496285	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	11053430	MGI
involved in primitive streak formation	IMP IMP: Inferred from mutant phenotype	16397896	MGI
involved in regulation of DNA-binding transcription factor activity	IMP IMP: Inferred from mutant phenotype	22234993	MGI
involved in skeletal system development	IMP IMP: Inferred from mutant phenotype	17127413	MGI
involved in smoothened signaling pathway	IGI IGI: Inferred from genetic interaction	22234993	MGI
involved in stem cell differentiation	IDA IDA: Inferred from direct assay	17267691	MGI
involved in stem cell population maintenance	IMP IMP: Inferred from mutant phenotype	17267691	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	15207726	MGI
located in nucleus	IDA IDA: Inferred from direct assay	11238441	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
zinc finger protein ZIC 3	Zic family member 3 (odd-paired homolog, Drosophila)

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16075	ZIC3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20353	Zic3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26862	Zic3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Zic3	NCBI	NCBI:7547