NID2 - nidogen 2 Gene

Also Known as NID-2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 22795

About NID2

Cytogenetic location: 14q22.1 Genomic coordinates (GRCh38): 14:52,004,809-52,069,059 (from NCBI)

This gene has 7 transcripts (splice variants), 210 orthologues and 14 paralogues. Broad expression in placenta (RPKM 30.5), thyroid (RPKM 21.7) and 16 other tissues.

Summary

This gene encodes a member of the nidogen family of basement membrane proteins. This protein is a cell-adhesion protein that binds collagens I and IV and laminin and may be involved in maintaining the structure of the basement membrane.[provided by RefSeq, Jun 2010]

NID2 Products (1)

mRNA Protein Name
NM_007361.4 NP_031387.3 nidogen-2 precursor

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
11956183 GOA
Cellular Component GO Annotation Evidence References Source
located in basement membrane IDA
IDA: Inferred from direct assay
22952693 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NID2 Protein Structure

NIDO

NIDO: Nidogen-like (180 - 272)

G2F

G2F: G2F domain (526 - 715)

EGF_CA

EGF_CA: Calcium-binding EGF domain (801 - 842)

cEGF

cEGF: Complement Clr-like EGF-like (875 - 895)

EGF_3

EGF_3: EGF domain (896 - 929)

Thyroglobulin_1

Thyroglobulin_1: Thyroglobulin type-1 repeat (941 - 1005)

Thyroglobulin_1

Thyroglobulin_1: Thyroglobulin type-1 repeat (1019 - 1084)

Ldl_recept_b

Ldl_recept_b: Low-density lipoprotein receptor repeat class B (1199 - 1238)

Ldl_recept_b

Ldl_recept_b: Low-density lipoprotein receptor repeat class B (1241 - 1283)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1375 a.a.
Protein Preferred Names Protein Names

nidogen-2

  • osteonidogen

Related Diseases

Diseases Alias
Myasthenic Syndrome, Congenital, 19

  • Congenital Myasthenic Syndrome 19

  • CMS19

  • Myasthenic Syndrome, Congenital, Type 19
Clivus Chordoma

  • Chordoma Of Clivus
Porencephaly
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09295 NID2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22256 Nid2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28778 Nid2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus NID2 MGD MGI:1298229
Canis familiaris NID2 VGNC VGNC:59037
Macaca mulatta NID2 VGNC VGNC:75165
Bos taurus NID2 VGNC VGNC:32074
Rattus norvegicus NID2 RGD RGD:1311685
Others NID2 NCBI