Mettl8 - methyltransferase like 8 Gene

Also Known as Tip

Species: Mus musculus

Gene Type: protein coding
Gene ID: 228019

Summary

This locus encodes a member of the methyltransferase family, and is involved in chromatin remodeling. Transcripts from this locus can be induced or inhibited by cell stretch and affect cell differentiation in the myogenic or adipogenic pathways. Multiple transcript variants encoding different isoforms have been found for this gene. Additional splice variants have been described in the literature but they meet nonsense-mediated decay (NMD) criteria and are likely to be degraded as soon as they are transcribed. [provided by RefSeq, Jul 2008]

Mettl8 Products (2)

mRNA Protein Name
NM_001110512.3 NP_001103982.1 tRNA N(3)-methylcytidine methyltransferase METTL8, mitochondrial isoform b
NM_145524.4 NP_663499.2 tRNA N(3)-methylcytidine methyltransferase METTL8, mitochondrial isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables histone acetyltransferase activity IDA
IDA: Inferred from direct assay
15992539 MGI
enables mRNA methyltransferase activity IMP
IMP: Inferred from mutant phenotype
28655767 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within fat cell differentiation IDA
IDA: Inferred from direct assay
15992539 MGI
acts upstream of or within skeletal muscle tissue development IDA
IDA: Inferred from direct assay
15992539 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
15992539 MGI
located in nucleus IDA
IDA: Inferred from direct assay
15992539 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

tRNA N(3)-methylcytidine methyltransferase METTL8, mitochondrial

mRNA N(3)-methylcytidine methyltransferase METTL8

  • methyltransferase-like protein 8

  • tension induced/inhibited protein

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08370 METTL8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mettl8 NCBI NCBI:79828