MORC2 - MORC family CW-type zinc finger 2 Gene

Also Known as ZCW3; CMT2Z; DIGFAN; ZCWCC1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 22880

About MORC2

Cytogenetic location: 22q12.2 Genomic coordinates (GRCh38): 22:30,925,130-30,968,774 (from NCBI)

This gene has 17 transcripts (splice variants), 216 orthologues, 1 paralogue and is associated with 4 phenotypes. Broad expression in testis (RPKM 20.8), ovary (RPKM 5.3) and 24 other tissues.

Summary

This gene encodes a member of the Microrchidia (MORC) protein superfamily. The encoded protein is known to regulate the condensation of heterochromatin in response to DNA damage and play a role in repressing transcription. The protein has been found to regulate the activity of ATP Citrate Lyase via specific interaction with this enzyme in the cytosol of lipogenic Breast Cancer cells. The protein also plays a role in lipogenesis and adipocyte differentiation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2016]

MORC2 Products (3)

mRNA	Protein	Name
NM_001303256.3	NP_001290185.1	ATPase MORC2 isoform 1
NM_001303257.2	NP_001290186.1	ATPase MORC2 isoform 2
NM_014941.3	NP_055756.1	ATPase MORC2 isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ATP binding	IDA IDA: Inferred from direct assay	29440755	GOA
enables ATP hydrolysis activity	IDA IDA: Inferred from direct assay	23260667	GOA
enables chromatin binding	IDA IDA: Inferred from direct assay	23260667	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	29440755	GOA
enables magnesium ion binding	IDA IDA: Inferred from direct assay	29440755	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	28514442	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	29440755	GOA
enables zinc ion binding	IDA IDA: Inferred from direct assay	29440755	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in DNA damage response	IDA IDA: Inferred from direct assay	23260667	GOA
involved in chromatin remodeling	IDA IDA: Inferred from direct assay	23260667	GOA
involved in negative regulation of gene expression, epigenetic	IDA IDA: Inferred from direct assay	28581500	GOA
involved in negative regulation of single stranded viral RNA replication via double stranded DNA intermediate	IMP IMP: Inferred from mutant phenotype	29211708	GOA
involved in positive regulation of DNA methylation-dependent heterochromatin formation	IDA IDA: Inferred from direct assay	28581500	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	23260667	GOA
located in heterochromatin	IDA IDA: Inferred from direct assay	28581500	GOA
located in nuclear matrix	IDA IDA: Inferred from direct assay	23260667	GOA
located in nucleus	IDA IDA: Inferred from direct assay	23260667	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MORC2 Protein Structure

HATPase_c_3

zf-CW

0
200
400
600
800
1032 a.a.

Protein Preferred Names	Protein Names
ATPase MORC2	zinc finger CW-type coiled-coil domain protein 1

Related Diseases

Diseases	Alias
Charcot-Marie-Tooth Disease, Axonal, Type 2z	CMT2Z Charcot-Marie-Tooth Disease Axonal Type 2z Charcot-Marie-Tooth Disease, Axonal, Autosomal Dominant, Type 2z Charcot-Marie-Tooth Neuropathy, Type 2z Autosomal Dominant Axonal Charcot-Marie-Tooth Disease Type 2z Charcot-Marie-Tooth Neuropathy Type 2z Autosomal Dominant Charcot-Marie-Tooth Disease Type 2z Autosomal Dominant Charcot-Marie-Tooth Disease Type 2 Due To Morc2 Mutation Charcot-Marie-Tooth Disease 2z Charcot-Marie-Tooth Disease, Type 2z
Developmental Delay, Impaired Growth, Dysmorphic Facies, And Axonal Neuropathy	DIGFAN
Charcot-Marie-Tooth Disease	Cmt Hmsn Hereditary Motor And Sensory Neuropathy Pma Cmt - Charcot-Marie-Tooth Disease Charcot Marie Tooth Disease Charcot-Marie-Tooth Hereditary Neuropathy Charcot-Marie-Tooth Syndrome Peroneal Muscular Atrophy Hereditary Motor And Sensory Neuropathies
Axonal Neuropathy
Tooth Disease	Tooth Diseases Teeth Disease Tooth Disorders
Charcot-Marie-Tooth Disease, X-Linked Recessive, 3	CMTX3 Charcot-Marie-Tooth Disease X-Linked Recessive 3 Charcot-Marie-Tooth Neuropathy, X-Linked Recessive, 3 Cmt3x X-Linked Charcot-Marie-Tooth Disease Type 3 Charcot-Marie-Tooth Neuropathy X-Linked Recessive 3 Charcot-Marie-Tooth Disease, X-Linked Type 3, Recessive
Charcot-Marie-Tooth Disease, Axonal, Type 2e	Charcot-Marie-Tooth Disease Type 2 CMT2E CMT2S CMT2Y Charcot-Marie-Tooth Disease Type 2e Charcot-Marie-Tooth Disease Type 2y Charcot-Marie-Tooth Disease Axonal Type 2s Charcot-Marie-Tooth Disease, Axonal, Type 2s Charcot-Marie-Tooth Disease, Type 2e Hereditary Motor And Sensory Neuropathy Type 2 Charcot-Marie-Tooth Neuropathy, Type 2s Charcot-Marie-Tooth Disease, Axonal, Autosomal Recessive, Type 2s Charcot-Marie-Tooth Disease, Axonal, Type 2y Charcot-Marie-Tooth Disease, Axonal, Autosomal Dominant, Type 2y Charcot-Marie-Tooth Neuropathy, Type 2y Charcot-Marie-Tooth Disease, Type 2y Autosomal Dominant Charcot-Marie-Tooth Disease Type 2e Charcot-Marie-Tooth Neuropathy Type 2e Autosomal Dominant Charcot-Marie-Tooth Disease Type 2 Due To Vcp Mutation Cmt2 Due To Vcp Mutation Charcot-Marie-Tooth Disease Type 2s Autosomal Dominant Charcot-Marie-Tooth Disease Type 2 Autosomal Dominant Axonal Charcot-Marie-Tooth Disease Cmt2 Charcot-Marie-Tooth Neuropathy, Type 2e Hereditary Motor And Sensory Neuropathy Guadalajara Neuronal Type Hereditary Motor And Sensory Neuropathy Okinawa Type Autosomal Dominant Axonal Charcot-Marie-Tooth Type 2y Charcot-Marie-Tooth Neuropathy Type 2y Autosomal Recessive Axonal Charcot-Marie-Tooth Type 2s Charcot-Marie-Tooth Neuropathy Type 2s Charcot-Marie-Tooth Type 2 Autosomal Dominant Charcot-Marie-Tooth Disease Type 2y Charcot-Marie-Tooth Disease 2e Charcot-Marie-Tooth Disease Axonal Type 2e Charcot-Marie-Tooth Disease Neuronal Type 2e Charcot-Marie-Tooth Disease 2s Charcot-Marie-Tooth Neuropathy Axonal Type 2s Charcot-Marie-Tooth Disease 2y Charcot-Marie-Tooth Disease, Type 2 Hereditary Motor And Sensory-Neuropathy Type Ii
Lynch Syndrome I	Lynch Syndrome 1 Colorectal Cancer, Hereditary Nonpolyposis, Type 1 HNPCC1 Fcc1 Lynch Syndrome Ii Colon Cancer, Familial Nonpolyposis, Type 1 Coca1 Familial Nonpolyposis Colon Cancer Type 1 Hereditary Nonpolyposis Colorectal Cancer Type 1 Hereditary Non-Polyposis Colorectal Cancer 1 Hereditary Non-Polyposis Colorectal Cancer 3 Hnpcc3 Lynch Cancer Family Syndrome Lynch Syndrome Lynch Syndrome Type I Lynch Syndrome Type Ii Cancer, Colorectal, Nonpolyposis, Hereditary, Type 1 Hereditary Nonpolyposis Colorectal Cancer Colorectal Cancer, Hereditary Nonpolyposis, Type 3 Hereditary Non-Polyposis Colon Cancer Type 2
Spinal Muscular Atrophy, Distal, Autosomal Recessive, 1	Smard1 DSMA1 Sianrf Dhmn6 Spinal Muscular Atrophy With Respiratory Distress 1 HMN6 Severe Infantile Axonal Neuropathy With Respiratory Failure Autosomal Recessive Distal Spinal Muscular Atrophy 1 Diaphragmatic Spinal Muscular Atrophy Spinal Muscular Atrophy With Respiratory Distress Type 1 Neuronopathy, Distal Hereditary Motor, Type Vi Hmn Vi Neuronopathy, Severe Infantile Axonal, With Respiratory Failure Distal Spinal Muscular Atrophy 1 Autosomal Recessive Spinal Muscular Atrophy With Respiratory Distress Distal Hereditary Motor Neuropathy Type 6 Distal-Hmn Type 6 Severe Infantile Axonal Neuropathy With Respiratory Failure Type 1 Spinal Muscular Atrophy, Diaphragmatic Distal Hereditary Motor Neuronopathy Type Vi Distal Spinal Muscular Atrophy Type 1 Hmnvi Spinal Muscular Atrophy With Respiratory Distress Autosomal Recessive Distal Spinal Muscular Atrophy Type 1 Neuronopathy, Distal Hereditary Motor, 6 Dhmn Vi Distal Hereditary Motor Neuropathy Type Vi Severe Infantile Axonal Neuronopathy With Respiratory Failure Spinal Muscular Atrophy Distal Autosomal Recessive 1 Atrophy, Muscular, Spinal, Distal, Type 1
Muscular Atrophy	Muscle Wasting Amyotrophia Wasting - Muscle Skeletal Muscle Atrophy
Autosomal Recessive Distal Hereditary Motor Neuronopathy	Autosomal Recessive Distal Spinal Muscular Atrophy
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Neuromuscular Disease	Neuromuscular Diseases Neuromuscular Disorders Neuromuscular Disorder
Microcephaly	Microencephaly Microcephalus Microcephalic Nanocephaly Congenital Microcephaly Brain Hypoplasia Brain Nondevelopment Cephalic Hypoplasia Undeveloped Cerebrum Undeveloped Brain Micrencephalon Micrencephaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08590	MORC2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	MORC2	RGD	RGD:1310842
Felis catus	MORC2	VGNC	VGNC:63557
Canis familiaris	MORC2	VGNC	VGNC:43317
Bos taurus	MORC2	VGNC	VGNC:31555
Macaca mulatta	MORC2	VGNC	VGNC:74810
Mus musculus	MORC2	MGD	MGI:1921772
Others	MORC2	NCBI