ANKRD6 - ankyrin repeat domain 6 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 22881

About ANKRD6

Cytogenetic location: 6q15 Genomic coordinates (GRCh38): 6:89,433,152-89,633,834 (from NCBI)

This gene has 22 transcripts (splice variants), 220 orthologues and 2 paralogues. Ubiquitous expression in brain (RPKM 8.1), ovary (RPKM 5.5) and 25 other tissues.

Summary

Predicted to be involved in negative regulation of canonical Wnt signaling pathway and positive regulation of JNK cascade. Predicted to act upstream of or within positive regulation of Wnt signaling pathway, planar cell polarity pathway. Located in intracellular membrane-bounded organelle. [provided by Alliance of Genome Resources, Apr 2022]

ANKRD6 Products (5)

mRNA Protein Name
NM_001242809.2 NP_001229738.1 ankyrin repeat domain-containing protein 6 isoform a
NM_001242811.1 NP_001229740.1 ankyrin repeat domain-containing protein 6 isoform a
NM_001242813.1 NP_001229742.1 ankyrin repeat domain-containing protein 6 isoform c
NM_001242814.1 NP_001229743.1 ankyrin repeat domain-containing protein 6 isoform d
NM_014942.4 NP_055757.3 ankyrin repeat domain-containing protein 6 isoform b

ANKRD6 Protein Structure

Ank_2

Ank_2: Ankyrin repeats (3 copies) (14 - 105)

Ank

Ank: Ankyrin repeat (107 - 139)

Ank

Ank: Ankyrin repeat (141 - 172)

Ank_2

Ank_2: Ankyrin repeats (3 copies) (178 - 261)

  • 0
  • 200
  • 400
  • 600
  • 727 a.a.
Protein Preferred Names Protein Names

ankyrin repeat domain-containing protein 6

  • diego homolog

Related Diseases

Diseases Alias
Neural Tube Defects

  • Spina Bifida

  • Neural Tube Defect

  • NTD

  • Neural Tube Defects, Susceptibility To

  • Spinal Dysraphism

  • Spina Bifida, Susceptibility To

  • Rachischisis

  • Cleft Spine

  • Open Spine

  • Hydrocele Spinalis

  • Neural Tube Defect Nos

  • Sb - [Spina Bifida]

  • Spinal Hernia Nos

  • Spinal Fissure Nos
Ocular Motility Disease

  • Ocular Motility Disorders

  • Abnormality Of Eye Movement

  • Disorder Of Eye Movements

  • Eye Movement Disorder

  • Eye Movement Disorders
Strabismus

  • Strabismus, Susceptibility To

  • Strabismus, Susceptibility To, 1

  • Strabismus 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00733 ANKRD6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus ANKRD6 VGNC VGNC:53781
Rattus norvegicus ANKRD6 RGD RGD:1583731
Canis familiaris ANKRD6 VGNC VGNC:52103
Mus musculus ANKRD6 MGD MGI:2154278
Macaca mulatta ANKRD6 VGNC VGNC:81023
Felis catus ANKRD6 VGNC VGNC:102380
Others ANKRD6 NCBI