DENND3 - DENN domain containing 3 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 22898

About DENND3

Cytogenetic location: 8q24.3 Genomic coordinates (GRCh38): 8:141,128,589-141,195,804 (from NCBI)

This gene has 22 transcripts (splice variants), 284 orthologues and 3 paralogues. Broad expression in bone marrow (RPKM 17.0), lung (RPKM 14.2) and 23 other tissues.

Summary

Enables guanyl-nucleotide exchange factor activity. Predicted to be involved in cellular protein catabolic process; endosome to lysosome transport; and regulation of Rab protein signal transduction. Predicted to be located in cytosol. Predicted to be active in cytoplasmic vesicle. [provided by Alliance of Genome Resources, Apr 2022]

DENND3 Products (4)

mRNA Protein Name
NM_001352890.3 NP_001339819.2 DENN domain-containing protein 3 isoform 1
NM_001352891.3 NP_001339820.2 DENN domain-containing protein 3 isoform 3
NM_001362798.2 NP_001349727.1 DENN domain-containing protein 3 isoform 4
NM_014957.5 NP_055772.3 DENN domain-containing protein 3 isoform 2

DENND3 Protein Structure

uDENN

uDENN: uDENN domain (39 - 80)

DENN

DENN: DENN (AEX-3) domain (106 - 290)

dDENN

dDENN: dDENN domain (354 - 417)

WD40

WD40: WD domain, G-beta repeat (978 - 1017)

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  • 1198 a.a.
Protein Preferred Names Protein Names

DENN domain-containing protein 3

  • DENN/MADD domain containing 3

Related Diseases

Diseases Alias
Hirschsprung Disease 1

  • Hirschsprung Disease

  • Aganglionic Megacolon

  • Hscr

  • Hirschsprung'S Disease

  • Congenital Megacolon

  • Congenital Intestinal Aganglionosis

  • Colonic Aganglionosis

  • Hirschsprung Disease, Susceptibility To, 1

  • Hirschsprung Disease, Protection Against

  • HSCR1

  • Mgc

  • Pelvirectal Achalasia

  • Total Intestinal Aganglionosis

  • Megacolon, Aganglionic

  • Macrocolon

  • Hscr 1

  • Hirschsprung Disease Type 1

  • Hirschsprung Disease, Type 1

  • Congenital Dilatation Of Colon

  • Aganglionosis

  • Congenital Aganglionic Megacolon

  • Aganglionosis Of Colon

  • Bowel Aganglionosis

  • Colon Aganglionosis

  • Hirschsprung Megacolon
Sarcosinemia

  • Sarcosine Dehydrogenase Complex Deficiency

  • Sard Deficiency

  • Sardh Deficiency

  • SARCOS

  • Hypersarcosinemia

  • Sardhd

  • Demethylation Defect Of N-Methylglycine
Janus Kinase-3 Deficiency
Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome 1

  • Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome

  • Berdon Syndrome

  • MMIHS

  • Megacystis Microcolon Intestinal Hypoperistalsis Syndrome

  • Megacystis, Microcolon, Hypoperistalsis Syndrome

  • Visceral Myopathy

  • Mmih Syndrome

  • Megacystis-Microcolon-Intestinal Hypoperistalsis-Hydronephrosis Syndrome

  • MMIHS1

  • Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome, Mmih

  • Mmhs
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03687 DENND3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus DENND3 MGD MGI:2146009
Felis catus DENND3 VGNC VGNC:61436
Rattus norvegicus DENND3 RGD RGD:1311559
Bos taurus DENND3 VGNC VGNC:27998
Canis familiaris DENND3 VGNC VGNC:39889
Macaca mulatta DENND3 VGNC VGNC:71811
Others DENND3 NCBI