PLA2R1 - phospholipase A2 receptor 1 Gene

Also Known as PLA2R; PLA2-R; PLA2IR; CLEC13C; PLA2G1R

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 22925

About PLA2R1

Cytogenetic location: 2q24.2 Genomic coordinates (GRCh38): 2:159,923,933-160,062,615 (from NCBI)

This gene has 3 transcripts (splice variants), 194 orthologues and 4 paralogues. Broad expression in thyroid (RPKM 11.6), kidney (RPKM 5.9) and 16 other tissues.

Summary

This gene represents a Phospholipase A2 receptor. The encoded protein likely exists as both a transmembrane form and a soluble form. The transmembrane receptor may play a role in clearance of Phospholipase A2, thereby inhibiting its action. Polymorphisms at this locus have been associated with susceptibility to idiopathic membranous nephropathy. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Sep 2010]

PLA2R1 Products (3)

mRNA	Protein	Name
NM_001007267.3	NP_001007268.1	secretory phospholipase A2 receptor isoform 2 precursor
NM_001195641.2	NP_001182570.1	secretory phospholipase A2 receptor isoform 3 precursor
NM_007366.5	NP_031392.3	secretory phospholipase A2 receptor isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables phospholipase binding	IPI IPI: Inferred from physical interaction	7721806	GOA
enables signaling receptor activity	IDA IDA: Inferred from direct assay	7721806	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in oxidative stress-induced premature senescence	IMP IMP: Inferred from mutant phenotype	19197340	GOA
involved in positive regulation of DNA damage response, signal transduction by p53 class mediator	IMP IMP: Inferred from mutant phenotype	19197340	GOA
involved in positive regulation of cytokine production	IMP IMP: Inferred from mutant phenotype	15611272	GOA
involved in positive regulation of podocyte apoptotic process	IMP IMP: Inferred from mutant phenotype	25335547	GOA
involved in reactive oxygen species metabolic process	IDA IDA: Inferred from direct assay	19197340	GOA
involved in receptor-mediated endocytosis	IDA IDA: Inferred from direct assay	7721806	GOA
involved in replicative senescence	IMP IMP: Inferred from mutant phenotype	19197340	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cell surface	IDA IDA: Inferred from direct assay	15611272	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	12225974	GOA
part of receptor complex	IDA IDA: Inferred from direct assay	23382219	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PLA2R1 Protein Structure

fn2

Lectin_C

0
300
600
900
1200
1463 a.a.

Protein Preferred Names	Protein Names
secretory phospholipase A2 receptor	180 kDa secretory phospholipase A2 receptor

Related Diseases

Diseases	Alias
Membranous Nephropathy	Membranous Glomerulonephritis Glomerulonephritis, Membranous Idiopathic Membranous Nephropathy Idiopathic Membranous Glomerulonephritis MBNP Membranous Nephropathy, Susceptibility To Extramembranous Glomerulonephritis Mgn Membranous Gn Primary Membranous Glomerulonephritis Primary Membranous Nephropathy Nephropathy Membranous
Igg4-Related Disease	Multifocal Fibrosclerosis Igg4-Related Sclerosing Disease Igg4-Related Systemic Disease Immunoglobulin G4-Related Sclerosing Disease Hyper-Igg4 Disease Igg4-Associated Disease Igg4-Positive Multiorgan Lymphoproliferative Syndrome Igg4-Related Autoimmune Disease Igg4-Related Systemic Sclerosing Disease Igg4-Syndrome Multifocal Idiopathic Fibrosclerosis Systemic Igg4-Related Plasmacytic Syndrome Systemic Igg4-Related Sclerosing Syndrome Mediastinal Fibrosis, Familial Retroperitoneal Fibrosis, Familial Igg4-Rd
Nephrotic Syndrome, Type 7	Immunoglobulin-Mediated Membranoproliferative Glomerulonephritis Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 7 NPHS7 Nephrotic Syndrome Type 7 Ig-Mediated Membranoproliferative Glomerulonephritis Ig-Mediated Mpgn Immunoglobulin-Mediated Mpgn Nephrotic Syndrome, Type 7, With Membranoproliferative Glomerulonephritis Hemolytic Uremic Syndrome, Atypical 7 Nephrotic Syndrome Type 7 With Membranoptoliferative Glomerulonephritis Hemolytic Uremic Syndrome With Dgke Deficiency Hus With Dgke Deficiency Hemolytic Uremic Syndrome Atypical 7 AHUS7 Nephrotic Syndrome 7 Nephrotic Syndrome Type 7 With Membranoproliferative Glomerulonephritis
Glomerulonephritis	Bright'S Disease
Goodpasture Syndrome	Anti-Glomerular Basement Membrane Disease Anti-Gbm Disease Pulmonary Renal Syndrome Anti-Glomerular Basement Membrane Antibody Disease Glomerulonephritis - Pulmonary Hemorrhage Rapidly Progressive Glomerulonephritis With Pulmonary Hemorrhage Anti-Gbm Syndrome Goodpasture'S Syndrome Anti-Basement Membrane Glomerulonephritis
Autoimmune Disease Of Urogenital Tract
Kimura Disease	Kimura'S Disease Eosinophilic Lymphogranuloma Eosinophilic Granuloma Of Soft Tissue Eosinophilic Hyperplastic Lymphogranuloma Eosinophilic Lymphofollicular Granuloma Eosinophilic Lymphofolliculosis
Immunoglobulin Heavy Chain Amyloidosis	Ah Amyloidosis Heavy Chain Amyloidosis Amyloidosis Derived From Immunoglobulin Heavy Chain Ig Heavy-Chain-Associated Amyloidosis
Crescentic Glomerulonephritis	Idiopathic Crescentic Glomerulonephritis
Acute Proliferative Glomerulonephritis	Acute Glomerulonephritis With Lesion Of Proliferative Glomerulonephritis Acute Post-Streptococcal Glomerulonephritis
Bronchiectasis 3
Lipoid Nephrosis	Minimal Change Disease Minimal Change Glomerulonephritis Nephrotic Syndrome With Lesion Of Minimal Change Glomerulonephritis Nephrotic Syndrome With Lesion Of Minimal Change Nephrotic Syndrome Idiopathic Minimal Change Nephrotic Syndrome Mcns Minimal Change Glomerulopathy Minimal Change Nephrotic Syndrome Nephrotic Syndrome Minimal Change Nephrosis, Lipoid Glomerulonephritis, Minimal Change Nephrotic Syndrome, Minimal Change
Rapidly Progressive Glomerulonephritis	Glomerulonephritis Rapidly Progressive Idiopathic Crescentic Glomerulonephritis
Acute Diffuse Nephritis	Acute Diffuse Glomerulonephritis
Membranoproliferative Glomerulonephritis	Mesangiocapillary Glomerulonephritis Dense Deposit Disease Membranoproliferative Glomerulonephritis Type 2 Primary Membranoproliferative Glomerulonephritis Mesangiocapillary Glomerulonephritis, Type Ii Glomerulonephritis, Membranoproliferative Chronic Glomerulonephritis, Lobular Lobular Glomerulonephritis Ddd Glomerulonephritis Membranoproliferative Type 2 Mpgn 2 Membranoproliferative Glomerulonephritis Type Ii Mesangiocapillary Glomerulonephritis Type 2 Mpgn Primary Mpgn Glomerulonephritis Membranoproliferative Membranoproliferative Glomerulonephritis, Type Ii
Proliferative Glomerulonephritis
Anti-Basement Membrane Glomerulonephritis	Anti-Gbm Glomerulonephritis
Interstitial Nephritis	Nephritis, Interstitial Renal Tubulo-Interstitial Disease Nephritis Interstitial Nephritis, Tubulointerstitial
Immune-Complex Glomerulonephritis	Immune Complex Glomerulonephritis
Mesangial Proliferative Glomerulonephritis	Glomerulonephritis - Mesangial Proliferative Mesangial Proliferative Gn Mesangioproliferative Glomerulonephritis Glomerulonephritis Mesangial Proliferative
Iga Glomerulonephritis	Iga Nephropathy Glomerulonephritis, Iga Berger'S Iga Or Igg Nephropathy Focal Glomerulonephritis Primary Iga Nephropathy Segmental Glomerulonephritis Berger Disease Berger'S Disease Igan Nephritis, Iga Type Nephropathy Iga Glomerulonephritis Focal Iga Nephropathy, Susceptibility To Primary Immunoglobulin A Nephropathy
Focal Segmental Glomerulosclerosis	Familial Idiopathic Steroid-Resistant Nephrotic Syndrome Focal Glomerulosclerosis Fsgs Segmental Glomerulosclerosis Glomerulosclerosis, Focal Segmental Fgs Focal Glomerular Sclerosis Familial Idiopathic Nephrotic Syndrome Focal Sclerosis With Hyalinosis Glomerulosclerosis, Focal Glomerulosclerosis Focal Glomerulosclerosis, Segmental, Focal Focal Segmental Glomerulosclerosis, Not Otherwise Specified

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10635	PLA2R1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	PLA2R1	VGNC	VGNC:104550
Mus musculus	PLA2R1	MGD	MGI:102468
Rattus norvegicus	PLA2R1	RGD	RGD:1309777
Felis catus	PLA2R1	VGNC	VGNC:80306
Bos taurus	PLA2R1	VGNC	VGNC:32966
Canis familiaris	PLA2R1	VGNC	VGNC:44633
Others	PLA2R1	NCBI