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Gbp5 - guanylate binding protein 5 Gene

Also Known as Gbp5a; 5330409J06Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 229898

Summary

Predicted to enable GTP binding activity; GTPase activity; and protein homodimerization activity. Involved in positive regulation of cytokine production and positive regulation of innate immune response. Acts upstream of or within cellular response to interferon-gamma and response to bacterium. Located in cytoplasmic vesicle. Orthologous to human GBP5 (guanylate binding protein 5). [provided by Alliance of Genome Resources, Apr 2022]

Gbp5 Products (1)

mRNA	Protein	Name
NM_153564.2	NP_705792.2	guanylate-binding protein 5

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	22461501	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in activation of innate immune response	IMP IMP: Inferred from mutant phenotype	24739961	MGI
involved in cellular response to lipopolysaccharide	IMP IMP: Inferred from mutant phenotype	24715728	MGI
acts upstream of or within cellular response to type II interferon	IDA IDA: Inferred from direct assay	18025219	MGI
involved in cytolysis in another organism	IDA IDA: Inferred from direct assay	25774715	MGI
involved in cytolysis in another organism	IMP IMP: Inferred from mutant phenotype	24715728	MGI
involved in defense response to bacterium	IDA IDA: Inferred from direct assay	25774715	MGI
involved in defense response to bacterium	IMP IMP: Inferred from mutant phenotype	24715728	MGI
involved in positive regulation of AIM2 inflammasome complex assembly	IDA IDA: Inferred from direct assay	25774715	MGI
involved in positive regulation of cytokine production involved in inflammatory response	IMP IMP: Inferred from mutant phenotype	22461501	MGI
involved in positive regulation of innate immune response	IMP IMP: Inferred from mutant phenotype	22461501	MGI
involved in positive regulation of interleukin-1 beta production	IMP IMP: Inferred from mutant phenotype	22461501	MGI
involved in positive regulation of interleukin-18 production	IMP IMP: Inferred from mutant phenotype	22461501	MGI
involved in positive regulation of pyroptotic inflammatory response	IDA IDA: Inferred from direct assay	25774715	MGI
involved in positive regulation of pyroptotic inflammatory response	IMP IMP: Inferred from mutant phenotype	24715728	MGI
involved in protein targeting	IDA IDA: Inferred from direct assay	27693356	MGI
acts upstream of or within response to bacterium	IEP IEP: Inferred from expression pattern	23012479	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasmic vesicle	IDA IDA: Inferred from direct assay	18025219	MGI
is active in symbiont cell surface	IDA IDA: Inferred from direct assay	27693356	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
guanylate-binding protein 5	GBP-5 GTP-binding protein 5 guanine nucleotide-binding protein 5 guanylate nucleotide binding protein 5 muGBP-5

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05311	GBP5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18761	Gbp5 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25248	Gbp5 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Gbp5	NCBI	NCBI:115362