Gbp7 - guanylate binding protein 7 Gene

Also Known as GBP-7; 9830147J24Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 229900

Summary

Predicted to enable GTP binding activity and GTPase activity. Acts upstream of or within adhesion of symbiont to host and defense response to Other organism. Located in cytoplasmic vesicle and symbiont-containing vacuole membrane. Is expressed in thymus primordium. Orthologous to human GBP7 (guanylate binding protein 7). [provided by Alliance of Genome Resources, Apr 2022]

Gbp7 Products (2)

mRNA	Protein	Name
NM_001083312.2	NP_001076781.1	guanylate-binding protein 7
NM_145545.4	NP_663520.2	guanylate-binding protein 7

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables GTP binding	IMP IMP: Inferred from mutant phenotype	31689351	MGI
enables GTPase activity	IMP IMP: Inferred from mutant phenotype	21551061	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	21551061	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in activation of innate immune response	IMP IMP: Inferred from mutant phenotype	24739961	MGI
acts upstream of or within adhesion of symbiont to host	IDA IDA: Inferred from direct assay	18025219	MGI
involved in cellular response to interferon-beta	IDA IDA: Inferred from direct assay	18025219	MGI
acts upstream of or within cellular response to type II interferon	IDA IDA: Inferred from direct assay	18025219	MGI
involved in cytolysis in another organism	IMP IMP: Inferred from mutant phenotype	24739961	MGI
acts upstream of or within defense response to Gram-positive bacterium	IDA IDA: Inferred from direct assay	18025219	MGI
involved in defense response to bacterium	IMP IMP: Inferred from mutant phenotype	24739961	MGI
acts upstream of or within defense response to protozoan	IDA IDA: Inferred from direct assay	18025219	MGI
acts upstream of or within defense response to protozoan	IMP IMP: Inferred from mutant phenotype	21551061	MGI
involved in defense response to protozoan	IMP IMP: Inferred from mutant phenotype	31964735	MGI
involved in defense response to virus	IDA IDA: Inferred from direct assay	33408175	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasmic vesicle	IDA IDA: Inferred from direct assay	18025219	MGI
located in symbiont-containing vacuole membrane	IDA IDA: Inferred from direct assay	18025219	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
guanylate-binding protein 7	GTP-binding protein 7 guanine nucleotide-binding protein 7 guanylate-binding protein 4-like

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05313	GBP7 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Gbp7	NCBI	NCBI:388646