2. Gene
  3. Clca2 - chloride channel accessory 2 Gene

Clca2 - chloride channel accessory 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Clca5; 4732440A06

Gene ID: 229933 | Gene type: protein coding

About Clca2

Summary

This gene encodes a member of the calcium-activated Chloride Channel regulator (CLCR) family of proteins. Members of this family regulate the transport of chloride across the plasma membrane. Expression of this gene is upregulated by the tumor suppressor protein p53 in response to DNA damage. Mice lacking a functional copy of this gene exhibit increased liver weight and hepatocyte hypertrophy. [provided by RefSeq, Sep 2016]

Clca2 Products(2)

mRNA Protein Name
NM_001409792.1 NP_001396721.1 calcium-activated chloride channel regulator 2 isoform 2
NM_178697.6 NP_848812.1 calcium-activated chloride channel regulator 2 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables chloride channel activity IDA
IDA: Inferred from direct assay
15284223 MGI
enables chloride channel activity IMP
IMP: Inferred from mutant phenotype
15284223 MGI
enables ligand-gated monoatomic ion channel activity IDA
IDA: Inferred from direct assay
15284223 MGI
enables ligand-gated monoatomic ion channel activity IMP
IMP: Inferred from mutant phenotype
15284223 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within chloride transport IMP
IMP: Inferred from mutant phenotype
15284223 MGI
Cellular Component GO Annotation Evidence Reference Source
located in plasma membrane IDA
IDA: Inferred from direct assay
15284223 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

calcium-activated chloride channel regulator 2

calcium-activated chloride channel family member 5

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS02749 CLCA2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Clca2 NCBI NCBI:9635