FOXL1 - forkhead box L1 Gene

Also Known as FKH6; FKHL11; FREAC7

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 2300

About FOXL1

Cytogenetic location: 16q24.1 Genomic coordinates (GRCh38): 16:86,578,549-86,583,478 (from NCBI)

This gene has 2 transcripts (splice variants), 169 orthologues and 42 paralogues.

Summary

This gene encodes a member of the forkhead/winged helix-box (FOX) family of transcription factors. FOX transcription factors are characterized by a distinct DNA-binding forkhead domain and play critical roles in the regulation of multiple processes including metabolism, cell proliferation and gene expression during ontogenesis. [provided by RefSeq, Nov 2012]

FOXL1 Products (1)

mRNA Protein Name
NM_005250.3 NP_005241.1 forkhead box protein L1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
7957066 GOA
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
7957066 GOA
Biological Process GO Annotation Evidence References Source
involved in heart development IMP
IMP: Inferred from mutant phenotype
21457232 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
34633540 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FOXL1 Protein Structure

Forkhead

Forkhead: Forkhead domain (49 - 143)

  • 0
  • 100
  • 200
  • 300
  • 345 a.a.
Protein Preferred Names Protein Names

forkhead box protein L1

  • forkhead-like 11

Related Diseases

Diseases Alias
Lymphedema-Distichiasis Syndrome

  • Lymphedema With Distichiasis

  • Lymphedema-Distichiasis Syndrome With Renal Disease And Diabetes Mellitus

  • LPHDST

  • Distichiasis-Lymphedema Syndrome

  • Lymphedema Distichiasis Syndrome

  • Hereditary Lymphedema-Distichiasis Syndrome

  • Lymphedema Distichiasis
Hypoplastic Left Heart Syndrome

  • Hlhs

  • Heart, Hypoplastic Left, Syndrome

  • Hypoplasia Of The Left Heart

  • Left Heart Hypoplasia Syndrome

  • Hlhs - [Hypoplastic Left Heart Syndrome]

  • Hypoplasia Of Aortic Valve, In Hypoplastic Left Heart Syndrome

  • Atresia Of Mitral Valve, In Hypoplastic Left Heart Syndrome

  • Atresia Or Marked Hypoplasia Of Aortic Orifice Or Valve, With Hypoplasia Of Ascending Aorta And Defective Development Of Left Ventricle

  • Atresia Or Marked Hypoplasia, Of Aortic Orifice Or Valve, With Hypoplasia Of Ascending Aorta And Defective Development Of Left Ventricle With Mitral Valve Atresia

  • Aortic Valve Atresia, In Hypoplastic Left Heart Syndrome

  • Ascending Aorta Hypoplasia, In Hypoplastic Left Heart Syndrome
Otosclerosis

  • Otospongiosis
Vacterl Association

  • Vater Association

  • Vater Syndrome
Pancreas, Annular

  • Annular Pancreas

  • Pancreas Annulare

  • Congenital Annular Pancreas
Microphthalmia, Syndromic 3

  • MCOPS3

  • Aeg Syndrome

  • Microphthalmia And Esophageal Atresia Syndrome

  • Anophthalmia/Microphthalmia-Esophageal Atresia Syndrome

  • Anophthalmia-Esophageal-Genital Syndrome

  • Optic Nerve Hypoplasia And Abnormalities Of The Central Nervous System

  • Syndromic Microphthalmia 3

  • Sox2 Anophthalmia Syndrome

  • Anophthalmia Clinical With Associated Anomalies

  • Anophthalmia Esophageal Genital Syndrome

  • Anophthalmia Microphthalmia Esophageal Atresia

  • Syndromic Microphthalmia Type 3

  • Sox2-Related Eye Disorders

  • Anophthalmia, Clinical, With Associated Anomalies

  • Syndromic Microphthalmia, Type 3

  • Microphthalmia, Syndromic, 3

  • Anophthalmia/Microphthalmia-Esophageal Atresia

  • Microphthalmia Syndromic, Type 3
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05061 FOXL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris FOXL1 VGNC VGNC:40958
Rattus norvegicus FOXL1 RGD RGD:1584212
Bos taurus FOXL1 VGNC VGNC:29092
Mus musculus FOXL1 MGD MGI:1347469
Others FOXL1 NCBI