MYO16 - myosin XVI Gene

Also Known as MYR8; MYAP3; NYAP3; Myo16b; PPP1R107

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23026

About MYO16

Cytogenetic location: 13q33.3 Genomic coordinates (GRCh38): 13:108,495,716-109,208,005 (from NCBI)

This gene has 6 transcripts (splice variants), 191 orthologues and 43 paralogues. Biased expression in brain (RPKM 1.6), fat (RPKM 1.1) and 8 other tissues.

Summary

This gene encodes an unconventional Myosin protein. The encoded protein has been proposed to act as a serine/threonine phosphatase-1 targeting or regulatory subunit. Studies in a rat cell line suggest that this protein may regulate cell cycle progression. A variant within this gene may be associated with susceptibility to schizophrenia and elevated expression of this gene has been observed in the frontal cortex of human schizophrenia patients. [provided by RefSeq, Mar 2017]

MYO16 Products (2)

mRNA Protein Name
NM_001198950.3 NP_001185879.1 unconventional myosin-XVI isoform 1
NM_015011.3 NP_055826.1 unconventional myosin-XVI isoform 2

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25902260 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleoplasm IDA
IDA: Inferred from direct assay
17029291 GOA
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
17029291 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MYO16 Protein Structure

Ank_2

Ank_2: Ankyrin repeats (3 copies) (67 - 156)

Ank_2

Ank_2: Ankyrin repeats (3 copies) (205 - 285)

Myosin_head

Myosin_head: Myosin head (motor domain) (404 - 1133)

NYAP_N

NYAP_N: Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter (1208 - 1576)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1500
  • 1858 a.a.
Protein Preferred Names Protein Names

unconventional myosin-XVI

  • MYO16 variant protein

Related Diseases

Diseases Alias
Schizophrenia

  • SCZD

  • Schizophrenia With Or Without An Affective Disorder

  • Schizophrenia 12

  • Schizophrenia, Susceptibility To

  • Schizophrenia-1

  • Dementia Praecox

  • Schizophrenia 1
Autism

  • Autistic Disorder

  • Autism Susceptibility 1

  • Childhood Autism

  • Autistic Disorder Of Childhood Onset

  • Infantile Autism

  • Kanner'S Syndrome

  • Autistic
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08933 MYO16 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta MYO16 VGNC VGNC:75042
Mus musculus MYO16 MGD MGI:2685951
Bos taurus MYO16 VGNC VGNC:53825
Canis familiaris MYO16 VGNC VGNC:43556
Rattus norvegicus MYO16 RGD RGD:621561
Felis catus MYO16 VGNC VGNC:102258
Others MYO16 NCBI