WDTC1 - WD and tetratricopeptide repeats 1 Gene

Homo sapiens

Also known as ADP; DCAF9

Gene ID: 23038 | Gene type: protein coding

About WDTC1

Cytogenetic location: 1p36.11 Genomic coordinates (GRCh38): 1:27,234,441-27,308,636 (from NCBI)

This gene has 5 transcripts (splice variants), 207 orthologues and 5 paralogues. Ubiquitous expression in testis (RPKM 28.2), heart (RPKM 14.1) and 25 other tissues.

Summary

Predicted to enable Enzyme inhibitor activity; histone binding activity; and histone deacetylase binding activity. Predicted to be involved in negative regulation of fatty acid biosynthetic process. Predicted to act upstream of or within several processes, including cellular response to Insulin stimulus; glucose metabolic process; and negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of Cul4-RING E3 ubiquitin ligase complex. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

WDTC1 Products(3)

mRNA	Protein	Name
NM_001276252.2	NP_001263181.1	WD and tetratricopeptide repeats protein 1 isoform a
NM_001410767.1	NP_001397696.1	WD and tetratricopeptide repeats protein 1 isoform c
NM_015023.5	NP_055838.2	WD and tetratricopeptide repeats protein 1 isoform b

WDTC1 Protein Structure

WD40

TPR_11

TPR_2

WD40

0
200
400
600
677 a.a.

Protein Preferred Names

Protein Names

WD and tetratricopeptide repeats protein 1

DDB1 and CUL4 associated factor 9

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15804	WDTC1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	WDTC1	RGD	RGD:1310362
Felis catus	WDTC1	VGNC	VGNC:67067
Mus musculus	WDTC1	MGD	MGI:2685541
Canis familiaris	WDTC1	VGNC	VGNC:48400
Macaca mulatta	WDTC1	VGNC	VGNC:79784
Bos taurus	WDTC1	VGNC	VGNC:107027

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