ZSWIM8 - zinc finger SWIM-type containing 8 Gene

Also Known as KIAA0913

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23053

About ZSWIM8

Cytogenetic location: 10q22.2 Genomic coordinates (GRCh38): 10:73,785,606-73,801,793 (from NCBI)

This gene has 23 transcripts (splice variants), 210 orthologues and 3 paralogues. Ubiquitous expression in testis (RPKM 21.6), spleen (RPKM 16.0) and 25 other tissues.

Summary

Enables ubiquitin ligase-substrate adaptor activity. Involved in positive regulation of miRNA catabolic process; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein ubiquitination. Part of Cul3-RING ubiquitin Ligase complex. [provided by Alliance of Genome Resources, Apr 2022]

ZSWIM8 Products (4)

mRNA Protein Name
NM_001242487.2 NP_001229416.1 zinc finger SWIM domain-containing protein 8 isoform 2
NM_001242488.2 NP_001229417.1 zinc finger SWIM domain-containing protein 8 isoform 3
NM_001367799.1 NP_001354728.1 zinc finger SWIM domain-containing protein 8 isoform 4
NM_015037.4 NP_055852.2 zinc finger SWIM domain-containing protein 8 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ubiquitin-like ligase-substrate adaptor activity IDA
IDA: Inferred from direct assay
33184234 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of miRNA catabolic process IDA
IDA: Inferred from direct assay
33184234 GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
33184234 GOA
involved in protein ubiquitination IDA
IDA: Inferred from direct assay
33184234 GOA
involved in target-directed miRNA degradation IMP
IMP: Inferred from mutant phenotype
33184237 GOA
Cellular Component GO Annotation Evidence References Source
part of Cul3-RING ubiquitin ligase complex IDA
IDA: Inferred from direct assay
33184234 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

zinc finger SWIM domain-containing protein 8

Related Diseases

Diseases Alias
Acromelic Frontonasal Dysostosis

  • AFND

  • Acromelic Frontonasal Dysplasia

  • Frontonasal Dysplasia Acromelic

  • Toriello Syndrome

  • Dysostosis, Acromelic Frontonasal

  • Sweet Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS16206 ZSWIM8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus ZSWIM8 VGNC VGNC:37388
Canis familiaris ZSWIM8 VGNC VGNC:48861
Felis catus ZSWIM8 VGNC VGNC:67387
Macaca mulatta ZSWIM8 VGNC VGNC:79396
Rattus norvegicus ZSWIM8 RGD RGD:1309414
Mus musculus ZSWIM8 MGD MGI:1919156
Others ZSWIM8 NCBI