Tut4 - terminal uridylyl transferase 4 Gene

Also Known as PPAPD3; Tent3a; Zcchc11; mKIAA0191; 6030404K05Rik; 9230115F04Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 230594

Summary

Enables RNA uridylyltransferase activity and miRNA binding activity. Involved in several processes, including RNA metabolic process; interleukin-6-mediated signaling pathway; and positive regulation of interleukin-6 production. Acts upstream of or within negative regulation of NF-kappaB transcription factor activity and regulation of lipopolysaccharide-mediated signaling pathway. Located in cytoplasm and nucleus. Is expressed in 1-cell stage embryo; 2-cell stage embryo; primary oocyte; and secondary oocyte. Human ortholog(s) of this gene implicated in liver benign neoplasm. Orthologous to human TUT4 (terminal uridylyl transferase 4). [provided by Alliance of Genome Resources, Apr 2022]

Tut4 Products (4)

mRNA	Protein	Name
NM_001379663.1	NP_001366592.1	terminal uridylyltransferase 4 isoform 1
NM_001379664.1	NP_001366593.1	terminal uridylyltransferase 4 isoform 2
NM_001379665.1	NP_001366594.1	terminal uridylyltransferase 4 isoform 4
NM_175472.4	NP_780681.2	terminal uridylyltransferase 4 isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables RNA uridylyltransferase activity	IDA IDA: Inferred from direct assay	19701194	MGI
enables miRNA binding	IDA IDA: Inferred from direct assay	28671666	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	16643855	MGI
enables uridylyltransferase activity	IDA IDA: Inferred from direct assay	28671666	MGI
enables uridylyltransferase activity	IMP IMP: Inferred from mutant phenotype	28792939	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in RNA 3' uridylation	IDA IDA: Inferred from direct assay	28671666	MGI
involved in RNA 3' uridylation	IMP IMP: Inferred from mutant phenotype	28792939	MGI
involved in RNA 3'-end processing	IDA IDA: Inferred from direct assay	19701194	MGI
acts upstream of or within cytokine production	IDA IDA: Inferred from direct assay	16643855	MGI
involved in interleukin-6-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	19701194	MGI
involved in miRNA metabolic process	IMP IMP: Inferred from mutant phenotype	19701194	MGI
acts upstream of or within negative regulation of NF-kappaB transcription factor activity	IDA IDA: Inferred from direct assay	16643855	MGI
involved in oocyte maturation	IMP IMP: Inferred from mutant phenotype	28792939	MGI
involved in polyuridylation-dependent mRNA catabolic process	IMP IMP: Inferred from mutant phenotype	28792939	MGI
involved in positive regulation of interleukin-6 production	IMP IMP: Inferred from mutant phenotype	19701194	MGI
acts upstream of or within regulation of lipopolysaccharide-mediated signaling pathway	IDA IDA: Inferred from direct assay	16643855	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	16643855	MGI
located in nucleus	IDA IDA: Inferred from direct assay	16643855	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
terminal uridylyltransferase 4	TUTase 4 zinc finger CCHC domain-containing protein 11 zinc finger, CCHC domain containing 11

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-169090	TS-002902	Inhibitor	98.29%	Unkown
HY-169091	TS-002266	Inhibitor	98.99%	Unkown
HY-RS15277	TUT4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tut4	NCBI	NCBI:23318