CMTR1 - cap methyltransferase 1 Gene

Also Known as MTr1; hMTr1; FTSJD2; KIAA0082

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23070

About CMTR1

Cytogenetic location: 6p21.2 Genomic coordinates (GRCh38): 6:37,423,985-37,481,508 (from NCBI)

This gene has 6 transcripts (splice variants), 200 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 31.1), spleen (RPKM 12.4) and 25 other tissues.

Summary

Enables mRNA (nucleoside-2'-O-)-methyltransferase activity. Involved in 7-methylguanosine mRNA capping and cap1 mRNA methylation. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

CMTR1 Products (1)

mRNA Protein Name
NM_015050.3 NP_055865.1 cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables mRNA (nucleoside-2'-O-)-methyltransferase activity IDA
IDA: Inferred from direct assay
20713356 GOA
Biological Process GO Annotation Evidence References Source
involved in 7-methylguanosine mRNA capping IDA
IDA: Inferred from direct assay
21310715 GOA
involved in 7-methylguanosine mRNA capping IMP
IMP: Inferred from mutant phenotype
20713356 GOA
involved in mRNA processing IDA
IDA: Inferred from direct assay
20713356 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
21310715 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CMTR1 Protein Structure

G-patch

G-patch: G-patch domain (88 - 129)

FtsJ

FtsJ: FtsJ-like methyltransferase (233 - 448)

  • 0
  • 200
  • 400
  • 600
  • 835 a.a.
Protein Preferred Names Protein Names

cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1

  • FtsJ methyltransferase domain containing 2

Related Diseases

Diseases Alias
Vaccinia
Murray Valley Encephalitis

  • Australian Encephalitis

  • Australian X Disease

  • Encephalitis Australia

  • Murray River Encephalitis

  • Australian Arboencephalitis

  • Australian X Disorder

  • Mve - [Murray Valley Encephalitis]
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02871 CMTR1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus CMTR1 VGNC VGNC:61004
Macaca mulatta CMTR1 VGNC VGNC:71271
Mus musculus CMTR1 MGD MGI:1921407
Bos taurus CMTR1 VGNC VGNC:27489
Rattus norvegicus CMTR1 RGD RGD:1307801
Canis familiaris CMTR1 VGNC VGNC:39385
Others CMTR1 NCBI