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Zmpste24 - zinc metallopeptidase, STE24 Gene

Also Known as MADB; FACE1; STE24; Face-1; Ste24p; D030046F19; A530043O15Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 230709

Summary

Enables double-stranded DNA binding activity and metalloendopeptidase activity. Acts upstream of or within several processes, including animal organ development; regulation of intracellular signal transduction; and regulation of nucleobase-containing compound metabolic process. Located in membrane and nuclear envelope. Is expressed in early conceptus. Used to study Emery-Dreifuss muscular dystrophy; familial partial lipodystrophy; and progeria. Human ortholog(s) of this gene implicated in connective tissue disease and lethal restrictive dermopathy. Orthologous to human ZMPSTE24 (zinc metallopeptidase STE24). [provided by Alliance of Genome Resources, Apr 2022]

Zmpste24 Products (1)

mRNA	Protein	Name
NM_172700.3	NP_766288.1	CAAX prenyl protease 1 homolog

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables double-stranded DNA binding	IGI IGI: Inferred from genetic interaction	23117660	MGI
enables endopeptidase activity	IDA IDA: Inferred from direct assay	17652517	MGI
enables metalloendopeptidase activity	IDA IDA: Inferred from direct assay	11399759	MGI
enables metalloendopeptidase activity	IMP IMP: Inferred from mutant phenotype	11399759	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within CAMKK-AMPK signaling cascade	IMP IMP: Inferred from mutant phenotype	18443001	MGI
acts upstream of or within DNA damage response	IMP IMP: Inferred from mutant phenotype	15980864	MGI
acts upstream of or within DNA repair	IGI IGI: Inferred from genetic interaction	21746928	MGI
acts upstream of or within DNA repair	IMP IMP: Inferred from mutant phenotype	15980864	MGI
acts upstream of or within adult walking behavior	IMP IMP: Inferred from mutant phenotype	11923874	MGI
acts upstream of or within bone mineralization	IGI IGI: Inferred from genetic interaction	23686339	MGI
acts upstream of or within calcium ion import into sarcoplasmic reticulum	IMP IMP: Inferred from mutant phenotype	27799555	MGI
acts upstream of or within cardiac conduction	IMP IMP: Inferred from mutant phenotype	27799555	MGI
acts upstream of or within cardiac muscle cell development	IMP IMP: Inferred from mutant phenotype	11923874	MGI
acts upstream of or within cardiac ventricle development	IMP IMP: Inferred from mutant phenotype	11923874	MGI
acts upstream of or within cellular lipid metabolic process	IMP IMP: Inferred from mutant phenotype	11923874	MGI
acts upstream of or within cellular response to gamma radiation	IMP IMP: Inferred from mutant phenotype	15980864	MGI
acts upstream of or within chromatin organization	IMP IMP: Inferred from mutant phenotype	16079796	MGI
acts upstream of or within chromosome organization	IMP IMP: Inferred from mutant phenotype	15980864	MGI
acts upstream of or within determination of adult lifespan	IGI IGI: Inferred from genetic interaction	21746928	MGI
acts upstream of or within determination of adult lifespan	IMP IMP: Inferred from mutant phenotype	11923874	MGI
acts upstream of or within epidermis development	IMP IMP: Inferred from mutant phenotype	11923874	MGI
acts upstream of or within epigenetic regulation of gene expression	IMP IMP: Inferred from mutant phenotype	20961378	MGI
acts upstream of or within growth plate cartilage development	IMP IMP: Inferred from mutant phenotype	11923874	MGI
acts upstream of or within hair follicle development	IMP IMP: Inferred from mutant phenotype	11923874	MGI
acts upstream of or within heart morphogenesis	IMP IMP: Inferred from mutant phenotype	11923874	MGI
acts upstream of or within inflammatory cell apoptotic process	IMP IMP: Inferred from mutant phenotype	11923874	MGI
acts upstream of or within kidney morphogenesis	IMP IMP: Inferred from mutant phenotype	11923874	MGI
acts upstream of or within liver development	IMP IMP: Inferred from mutant phenotype	23117660	MGI
acts upstream of or within maintenance of rDNA	IMP IMP: Inferred from mutant phenotype	20961378	MGI
acts upstream of or within multicellular organism growth	IGI IGI: Inferred from genetic interaction	23686339	MGI
acts upstream of or within multicellular organism growth	IMP IMP: Inferred from mutant phenotype	11923874	MGI
acts upstream of or within negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	16079796	MGI
acts upstream of or within negative regulation of miRNA processing	IGI IGI: Inferred from genetic interaction	21522133	MGI
acts upstream of or within negative regulation of miRNA processing	IMP IMP: Inferred from mutant phenotype	21522133	MGI
acts upstream of or within neuromuscular process	IGI IGI: Inferred from genetic interaction	23686339	MGI
acts upstream of or within neuromuscular process	IMP IMP: Inferred from mutant phenotype	11923874	MGI
involved in nuclear envelope organization	IDA IDA: Inferred from direct assay	17652517	MGI
acts upstream of or within nuclear envelope organization	IGI IGI: Inferred from genetic interaction	15608054	MGI
acts upstream of or within nuclear envelope organization	IMP IMP: Inferred from mutant phenotype	11923874	MGI
involved in nuclear envelope organization	IMP IMP: Inferred from mutant phenotype	12235369	MGI
acts upstream of or within nucleus organization	IGI IGI: Inferred from genetic interaction	16511604	MGI
acts upstream of or within nucleus organization	IMP IMP: Inferred from mutant phenotype	11923874	MGI
acts upstream of or within positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	27498005	MGI
acts upstream of or within positive regulation of gene expression via chromosomal CpG island demethylation	IMP IMP: Inferred from mutant phenotype	20961378	MGI
acts upstream of or within prenylated protein catabolic process	IDA IDA: Inferred from direct assay	11399759	MGI
involved in protein maturation	IDA IDA: Inferred from direct assay	17652517	MGI
involved in protein maturation	IMP IMP: Inferred from mutant phenotype	12235369	MGI
acts upstream of or within protein processing	IMP IMP: Inferred from mutant phenotype	11923874	MGI
acts upstream of or within regulation of DNA damage response, signal transduction by p53 class mediator	IGI IGI: Inferred from genetic interaction	21522133	MGI
acts upstream of or within regulation of DNA damage response, signal transduction by p53 class mediator	IMP IMP: Inferred from mutant phenotype	16079796	MGI
acts upstream of or within regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	20961378	MGI
acts upstream of or within regulation of RNA polymerase II regulatory region sequence-specific DNA binding	IMP IMP: Inferred from mutant phenotype	15980864	MGI
acts upstream of or within regulation of TOR signaling	IMP IMP: Inferred from mutant phenotype	18443001	MGI
acts upstream of or within regulation of autophagy	IMP IMP: Inferred from mutant phenotype	18443001	MGI
acts upstream of or within regulation of blood circulation	IMP IMP: Inferred from mutant phenotype	18443001	MGI
acts upstream of or within regulation of bone mineralization	IGI IGI: Inferred from genetic interaction	23695662	MGI
acts upstream of or within regulation of cell shape	IMP IMP: Inferred from mutant phenotype	16079796	MGI
acts upstream of or within regulation of cellular senescence	IGI IGI: Inferred from genetic interaction	23686339	MGI
acts upstream of or within regulation of cellular senescence	IMP IMP: Inferred from mutant phenotype	16079796	MGI
acts upstream of or within regulation of defense response to virus	IMP IMP: Inferred from mutant phenotype	28246125	MGI
acts upstream of or within regulation of fibroblast proliferation	IMP IMP: Inferred from mutant phenotype	16079796	MGI
acts upstream of or within regulation of glucose metabolic process	IMP IMP: Inferred from mutant phenotype	18443001	MGI
acts upstream of or within regulation of heart contraction	IMP IMP: Inferred from mutant phenotype	27799555	MGI
acts upstream of or within regulation of hormone metabolic process	IMP IMP: Inferred from mutant phenotype	18443001	MGI
acts upstream of or within regulation of lipid metabolic process	IMP IMP: Inferred from mutant phenotype	18443001	MGI
acts upstream of or within regulation of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	16079796	MGI
acts upstream of or within regulation of mitotic cell cycle DNA replication	IMP IMP: Inferred from mutant phenotype	15980864	MGI
acts upstream of or within regulation of multicellular organism growth	IGI IGI: Inferred from genetic interaction	23695662	MGI
acts upstream of or within regulation of stress-activated protein kinase signaling cascade	IMP IMP: Inferred from mutant phenotype	16079796	MGI
acts upstream of or within regulation of termination of RNA polymerase I transcription	IMP IMP: Inferred from mutant phenotype	20961378	MGI
acts upstream of or within regulation of ventricular cardiac muscle cell membrane repolarization	IMP IMP: Inferred from mutant phenotype	27799555	MGI
acts upstream of or within response to DNA damage checkpoint signaling	IMP IMP: Inferred from mutant phenotype	15980864	MGI
acts upstream of or within thymus development	IMP IMP: Inferred from mutant phenotype	11923874	MGI
acts upstream of or within ventricular cardiac muscle tissue development	IMP IMP: Inferred from mutant phenotype	27799555	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in membrane	IDA IDA: Inferred from direct assay	11399759	MGI
located in nuclear envelope	IDA IDA: Inferred from direct assay	15980864	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
CAAX prenyl protease 1 homolog	farnesylated-proteins converting enzyme 1 prenyl protein-specific endoprotease 1 zinc metallopeptidase, STE24 homolog zinc metalloproteinase, STE24 homolog

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16088	ZMPSTE24 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Zmpste24	NCBI	NCBI:10269