Hadhb - hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta Gene

Also Known as Mtpb; TP-beta; 4930479F15Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 231086

Summary

Enables acetyl-CoA C-acyltransferase activity. Predicted to be involved in fatty acid beta-oxidation. Predicted to act upstream of or within fatty acid metabolic process. Located in mitochondrion. Is expressed in heart; liver; and placenta. Human ortholog(s) of this gene implicated in Mitochondrial Metabolism disease and mitochondrial trifunctional protein deficiency. Orthologous to human HADHB (hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta). [provided by Alliance of Genome Resources, Apr 2022]

Hadhb Products (3)

mRNA Protein Name
NM_001289798.1 NP_001276727.1 trifunctional enzyme subunit beta, mitochondrial precursor
NM_001289799.1 NP_001276728.1 trifunctional enzyme subunit beta, mitochondrial precursor
NM_145558.2 NP_663533.1 trifunctional enzyme subunit beta, mitochondrial precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables acetyl-CoA C-acetyltransferase activity IDA
IDA: Inferred from direct assay
32513690 MGI
enables acetyl-CoA C-acyltransferase activity IDA
IDA: Inferred from direct assay
15240869 MGI
enables acetyl-CoA C-acyltransferase activity IMP
IMP: Inferred from mutant phenotype
17116638 MGI
enables lncRNA binding IDA
IDA: Inferred from direct assay
32513690 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
29949755 MGI
Biological Process GO Annotation Evidence References Source
involved in cellular response to lipopolysaccharide IDA
IDA: Inferred from direct assay
32513690 MGI
involved in gene expression IMP
IMP: Inferred from mutant phenotype
32513690 MGI
Cellular Component GO Annotation Evidence References Source
is active in mitochondrion IDA
IDA: Inferred from direct assay
32513690 MGI
located in mitochondrion IMP
IMP: Inferred from mutant phenotype
17116638 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

trifunctional enzyme subunit beta, mitochondrial

  • hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), beta aubunit

  • hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), b

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05991 HADHB Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18664 Hadhb Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25150 Hadhb Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hadhb NCBI NCBI:3032