Fras1 - Fraser extracellular matrix complex subunit 1 Gene

Also Known as bl; mKIAA1500; E130113P14Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 231470

Summary

Predicted to enable metal ion binding activity. Predicted to be an extracellular matrix structural constituent. Acts upstream of or within several processes, including animal organ development; embryonic limb morphogenesis; and roof of mouth development. Located in basement membrane. Is expressed in several structures, including alimentary system; body cavity or lining; brain; sensory organ; and skin. Used to study Fraser syndrome and clubfoot. Human ortholog(s) of this gene implicated in Fraser syndrome 1. Orthologous to human FRAS1 (Fraser extracellular matrix complex subunit 1). [provided by Alliance of Genome Resources, Apr 2022]

Fras1 Products (1)

mRNA Protein Name
NM_175473.3 NP_780682.3 extracellular matrix organizing protein FRAS1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
14730302 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within embryonic limb morphogenesis IMP
IMP: Inferred from mutant phenotype
23469164 MGI
acts upstream of or within metanephros morphogenesis IMP
IMP: Inferred from mutant phenotype
23469164 MGI
acts upstream of or within morphogenesis of an epithelium IMP
IMP: Inferred from mutant phenotype
15838507 MGI
acts upstream of or within protein transport IMP
IMP: Inferred from mutant phenotype
17596926 MGI
acts upstream of or within roof of mouth development IMP
IMP: Inferred from mutant phenotype
23469164 MGI
acts upstream of or within skin development IMP
IMP: Inferred from mutant phenotype
17596926 MGI
Cellular Component GO Annotation Evidence References Source
located in basement membrane IDA
IDA: Inferred from direct assay
15345741 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

extracellular matrix organizing protein FRAS1

extracellular matrix protein FRAS1

  • Fraser syndrome 1 homolog

  • Fraser syndrome 1 protein

  • blebbed

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-17663 KMR-206 98.86% Unkown
HY-RS05089 FRAS1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
Bioactive MoleculesInhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990417 Anti-FOLR1/FRA Antibody / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Fras1 NCBI NCBI:80144