CLCC1 - chloride channel CLIC like 1 Gene

Also Known as MCLC; RP32

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23155

About CLCC1

Cytogenetic location: 1p13.3 Genomic coordinates (GRCh38): 1:108,929,505-108,963,484 (from NCBI)

This gene has 88 transcripts (splice variants), 119 orthologues and is associated with 2 phenotypes. Ubiquitous expression in brain (RPKM 9.3), thyroid (RPKM 9.3) and 25 other tissues.

Summary

Predicted to enable Chloride Channel activity. Predicted to be involved in chloride transport. Located in endoplasmic reticulum and mitochondria-associated endoplasmic reticulum membrane. Implicated in retinitis pigmentosa 32. [provided by Alliance of Genome Resources, Apr 2022]

CLCC1 Products (17)

mRNA Protein Name
NM_001048210.3 NP_001041675.1 chloride channel CLIC-like protein 1 isoform 1 precursor
NM_001278202.2 NP_001265131.1 chloride channel CLIC-like protein 1 isoform 3 precursor
NM_001278203.1 NP_001265132.1 chloride channel CLIC-like protein 1 isoform 4 precursor
NM_001377458.1 NP_001364387.1 chloride channel CLIC-like protein 1 isoform 1 precursor
NM_001377459.1 NP_001364388.1 chloride channel CLIC-like protein 1 isoform 1 precursor
NM_001377460.1 NP_001364389.1 chloride channel CLIC-like protein 1 isoform 1 precursor
NM_001377461.1 NP_001364390.1 chloride channel CLIC-like protein 1 isoform 1 precursor
NM_001377462.1 NP_001364391.1 chloride channel CLIC-like protein 1 isoform 1 precursor
NM_001377463.1 NP_001364392.1 chloride channel CLIC-like protein 1 isoform 1 precursor
NM_001377464.1 NP_001364393.1 chloride channel CLIC-like protein 1 isoform 1 precursor
NM_001377465.1 NP_001364394.1 chloride channel CLIC-like protein 1 isoform 1 precursor
NM_001377466.1 NP_001364395.1 chloride channel CLIC-like protein 1 isoform 1 precursor
NM_001377467.1 NP_001364396.1 chloride channel CLIC-like protein 1 isoform 1 precursor
NM_001377468.1 NP_001364397.1 chloride channel CLIC-like protein 1 isoform 1 precursor
NM_001377469.1 NP_001364398.1 chloride channel CLIC-like protein 1 isoform 5 precursor
NM_001377470.1 NP_001364399.1 chloride channel CLIC-like protein 1 isoform 6
NM_015127.5 NP_055942.1 chloride channel CLIC-like protein 1 isoform 2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables chloride channel activity IDA
IDA: Inferred from direct assay
37142673 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
31653868 GOA
Biological Process GO Annotation Evidence References Source
involved in endoplasmic reticulum calcium ion homeostasis IMP
IMP: Inferred from mutant phenotype
37142673 GOA
Cellular Component GO Annotation Evidence References Source
located in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
37142673 GOA
located in mitochondria-associated endoplasmic reticulum membrane contact site IDA
IDA: Inferred from direct assay
31653868 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CLCC1 Protein Structure

MCLC

MCLC: Mid-1-related chloride channel (MCLC) (3 - 551)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 551 a.a.
Protein Preferred Names Protein Names

chloride channel CLIC-like protein 1

  • Mid-1-related chloride channel protein 1

Related Diseases

Diseases Alias
Retinitis Pigmentosa 32

  • RP32

  • Retinitis Pigmentosa-32
Retinitis Pigmentosa

  • RP

  • Rod-Cone Dystrophy

  • Autosomal Recessive Retinitis Pigmentosa

  • Non-Syndromic Retinitis Pigmentosa

  • Pericentral Pigmentary Retinopathy

  • Pigmentary Retinopathy

  • Tapetoretinal Degeneration

  • Rcd

  • Retinitis Pigmentosa Autosomal Recessive

  • ARRP

  • Retinitis Pigmentosa, Autosomal Recessive

  • Retinitis Pigmentosa 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02751 CLCC1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris CLCC1 VGNC VGNC:39299
Rattus norvegicus CLCC1 RGD RGD:708359
Bos taurus CLCC1 VGNC VGNC:27394
Felis catus CLCC1 VGNC VGNC:60921
Mus musculus CLCC1 MGD MGI:2385186
Macaca mulatta CLCC1 VGNC VGNC:71373
Others CLCC1 NCBI