Fbxw8 - F-box and WD-40 domain protein 8 Gene

Also Known as FBW6; FBW8; Fbx29; FBXO29; 4930438M06Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 231672

Summary

Predicted to contribute to ubiquitin-protein transferase activity. Involved in positive regulation of transcription factor catabolic process and protein ubiquitination. Acts upstream of or within labyrinthine layer blood vessel development and spongiotrophoblast layer development. Part of Cul7-RING ubiquitin Ligase complex and SCF ubiquitin Ligase complex. Is expressed in several structures, including heart; liver; lung; placenta; and spleen. Orthologous to human FBXW8 (F-box and WD repeat domain containing 8). [provided by Alliance of Genome Resources, Apr 2022]

Fbxw8 Products (1)

mRNA Protein Name
NM_172721.2 NP_766309.2 F-box/WD repeat-containing protein 8

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16880526 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within labyrinthine layer blood vessel development IMP
IMP: Inferred from mutant phenotype
16880526 MGI
involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
29153991 MGI
involved in protein ubiquitination IDA
IDA: Inferred from direct assay
29153991 MGI
acts upstream of or within spongiotrophoblast layer development IMP
IMP: Inferred from mutant phenotype
16880526 MGI
Cellular Component GO Annotation Evidence References Source
part of Cul7-RING ubiquitin ligase complex IDA
IDA: Inferred from direct assay
21572988 MGI
part of SCF ubiquitin ligase complex IPI
IPI: Inferred from physical interaction
16880526 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

F-box/WD repeat-containing protein 8

  • F-box and WD-40 domain-containing protein 8

  • F-box protein FBX29

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04819 FBXW8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Fbxw8 NCBI NCBI:26259