RFTN1 - raftlin, lipid raft linker 1 Gene

Also Known as MIG2; PIG9; PIB10; RAFTLIN

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23180

About RFTN1

Cytogenetic location: 3p24.3 Genomic coordinates (GRCh38): 3:16,315,845-16,513,699 (from NCBI)

This gene has 12 transcripts (splice variants), 291 orthologues and 1 paralogue. Broad expression in lymph node (RPKM 35.0), fat (RPKM 23.7) and 23 other tissues.

Summary

Enables double-stranded RNA binding activity. Involved in B cell receptor signaling pathway; membrane raft assembly; and positive regulation of growth rate. Acts upstream of or within dsRNA transport; response to exogenous dsRNA; and Toll-like Receptor 3 signaling pathway. Located in endosome; membrane raft; and plasma membrane. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]

RFTN1 Products (1)

mRNA Protein Name
NM_015150.2 NP_055965.1 raftlin

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables double-stranded RNA binding IDA
IDA: Inferred from direct assay
21266579 GOA
Biological Process GO Annotation Evidence References Source
involved in B cell receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
12805216 GOA
acts upstream of or within dsRNA transport IMP
IMP: Inferred from mutant phenotype
21266579 GOA
involved in membrane raft assembly IMP
IMP: Inferred from mutant phenotype
12805216 GOA
involved in positive regulation of growth rate IMP
IMP: Inferred from mutant phenotype
12805216 GOA
acts upstream of or within response to exogenous dsRNA IMP
IMP: Inferred from mutant phenotype
21266579 GOA
acts upstream of or within toll-like receptor 3 signaling pathway IMP
IMP: Inferred from mutant phenotype
21266579 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
21266579 GOA
located in endosome IDA
IDA: Inferred from direct assay
21266579 GOA
located in membrane raft IDA
IDA: Inferred from direct assay
12805216 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
12805216 GOA
part of protein-containing complex IDA
IDA: Inferred from direct assay
21266579 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RFTN1 Protein Structure

Raftlin

Raftlin: Raftlin (1 - 478)

  • 0
  • 100
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  • 500
  • 578 a.a.
Protein Preferred Names Protein Names

raftlin

  • cell migration-inducing gene 2 protein

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11877 RFTN1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus RFTN1 VGNC VGNC:109570
Canis familiaris RFTN1 VGNC VGNC:45500
Felis catus RFTN1 VGNC VGNC:64584
Rattus norvegicus RFTN1 RGD RGD:1563347
Mus musculus RFTN1 MGD MGI:1923688
Macaca mulatta RFTN1 VGNC VGNC:76867
Others RFTN1 NCBI