MESD - mesoderm development LRP chaperone Gene

Also Known as BOCA; OI20; MESDC2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 23184

About MESD

Cytogenetic location: 15q25.1 Genomic coordinates (GRCh38): 15:80,946,289-80,989,819 (from NCBI)

This gene has 7 transcripts (splice variants), 207 orthologues and is associated with 3 phenotypes. Ubiquitous expression in thyroid (RPKM 16.9), placenta (RPKM 10.6) and 25 other tissues.

Summary

Predicted to enable low-density lipoprotein particle receptor binding activity. Involved in ossification and protein folding. Located in endoplasmic reticulum. Implicated in osteogenesis imperfecta type 20. [provided by Alliance of Genome Resources, Apr 2022]

MESD Products (1)

mRNA	Protein	Name
NM_015154.3	NP_055969.1	LRP chaperone MESD precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in ossification	IMP IMP: Inferred from mutant phenotype	31564437	GOA
involved in protein folding	IMP IMP: Inferred from mutant phenotype	31564437	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in endoplasmic reticulum	IMP IMP: Inferred from mutant phenotype	31564437	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MESD Protein Structure

Mesd

0
100
200
234 a.a.

Protein Preferred Names	Protein Names
LRP chaperone MESD	LDLR chaperone MESD

MESD Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	MESD	Q14696	CENPH	Homo sapiens	Q9H3R5	Validated Y2H	32296183
Intra	MESD	Q14696	NRDE2	Homo sapiens	Q9H7Z3	Validated Y2H	32296183
Intra	MESD	Q14696	TEKTL1	Homo sapiens	Q8IYK2	Validated Y2H	32296183
Intra	MESD	Q14696	CENATAC	Homo sapiens	Q86UT8	Validated Y2H	32296183
Intra	MESD	Q14696	CDR2L	Homo sapiens	Q86X02	Validated Y2H	32296183
Intra	MESD	Q14696	LCE1A	Homo sapiens	Q5T7P2	Validated Y2H	32296183
Intra	MESD	Q14696	TEX12	Homo sapiens	Q9BXU0	Validated Y2H	32296183
Intra	MESD	Q14696	ZNF493	Homo sapiens	Q6ZR52-3	Validated Y2H	32296183
Intra	MESD	Q14696	CNOT9	Homo sapiens	Q92600-3	Validated Y2H	32296183
Intra	MESD	Q14696	C17orf75	Homo sapiens	Q9HAS0	Validated Y2H	32296183
Intra	MESD	Q14696	MKNK2	Homo sapiens	Q9HBH9-2	Validated Y2H	32296183
Intra	MESD	Q14696	RCOR3	Homo sapiens	Q9P2K3-2	Validated Y2H	32296183
Intra	MESD	Q14696	LY96	Homo sapiens	Q9Y6Y9	Validated Y2H	32296183
Intra	MESD	Q14696	ACBD7	Homo sapiens	Q8N6N7	Validated Y2H	32296183
Intra	MESD	Q14696	AKNAD1	Homo sapiens	Q5T1N1-2	Validated Y2H	32296183
Intra	MESD	Q14696	MCM9	Homo sapiens	Q9NXL9-3	Validated Y2H	32296183
Intra	MESD	Q14696	ADAL	Homo sapiens	Q6DHV7-2	Validated Y2H	32296183
Intra	MESD	Q14696	TREX2	Homo sapiens	Q9BQ50	Validated Y2H	32296183
Intra	MESD	Q14696	TRMT2A	Homo sapiens	Q8IZ69	Validated Y2H	32296183
Intra	MESD	Q14696	ARB2A	Homo sapiens	Q8WUF8	Validated Y2H	32296183
Intra	MESD	Q14696	CLP1	Homo sapiens	Q92989	Validated Y2H	32296183
Intra	MESD	Q14696	MAP1LC3B	Homo sapiens	Q9GZQ8	Validated Y2H	32296183
Intra	MESD	Q14696	ABCG8	Homo sapiens	Q9H221	Validated Y2H	32296183
Intra	MESD	Q14696	CYP4F11	Homo sapiens	Q9HBI6	Validated Y2H	32296183
Intra	MESD	Q14696	GOLGA7	Homo sapiens	Q7Z5G4	Validated Y2H	32296183
Intra	MESD	Q14696	ASH2L	Homo sapiens	Q9UBL3	Validated Y2H	32296183
Intra	MESD	Q14696	MRM1	Homo sapiens	Q6IN84	Validated Y2H	32296183
Intra	MESD	Q14696	CHCHD1	Homo sapiens	Q96BP2	Validated Y2H	32296183
Intra	MESD	Q14696	ZNF827	Homo sapiens	Q17R98	Validated Y2H	32296183
Intra	MESD	Q14696	COX14	Homo sapiens	Q96I36	Validated Y2H	32296183
Intra	MESD	Q14696	PMF1	Homo sapiens	Q6P1K2	Validated Y2H	32296183
Intra	MESD	Q14696	CUTC	Homo sapiens	Q9NTM9	Validated Y2H	32296183
Intra	MESD	Q14696	GTPBP3	Homo sapiens	Q969Y2	Validated Y2H	32296183
Intra	MESD	Q14696	UBQLN1	Homo sapiens	Q9UMX0	Validated Y2H	32296183
Intra	MESD	Q14696	AKIRIN2	Homo sapiens	Q53H80	Validated Y2H	32296183
Intra	MESD	Q14696	BORCS8	Homo sapiens	Q96FH0	Validated Y2H	32296183
Intra	MESD	Q14696	ENKD1	Homo sapiens	Q9H0I2	Validated Y2H	32296183
Intra	MESD	Q14696	GPKOW	Homo sapiens	Q92917	Validated Y2H	32296183
Intra	MESD	Q14696	FAM13C	Homo sapiens	Q8NE31	Validated Y2H	32296183
Intra	MESD	Q14696	ATP6V1E2	Homo sapiens	Q96A05	Validated Y2H	32296183
Intra	MESD	Q14696	TTC23	Homo sapiens	Q5W5X9-3	Validated Y2H	32296183
Intra	MESD	Q14696	ABITRAM	Homo sapiens	Q9NX38	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant MESD Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76492	MESDC2 Protein, Human (HEK293, His)	Q14696-1 (A34-K230)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Osteogenesis Imperfecta, Type Xx	OI20 Osteogenesis Imperfecta Type 20 Osteogenesis Imperfecta, Type 20 Osteogenesis Imperfecta Type Xx Osteogenesis Imperfecta 20
Osteogenesis Imperfecta, Type Ii	Vrolik Type Of Osteogenesis Imperfecta Osteogenesis Imperfecta Type 2 OI2 Oi, Type Ii Osteogenesis Imperfecta Congenita Oic Osteogenesis Imperfecta Type Ii Lethal Osteogenesis Imperfecta Oi Type 2 Osteogenesis Imperfecta Congenita Perinatal Lethal Form Osteogenesis Imperfecta Congenita, Perinatal Lethal Form Perinatal Lethal Osteogenesis Imperfecta Congenita Perinatally Lethal Oi Osteogenesis Imperfecta 2 Oi-Ii Oi-Iia Oi Type Iia Osteogenesis Imperfecta Type Iia Osteogenesis Imperfecta Type Ii Autosomal Dominant Oi Type Ii Osteogenesis Imperfecta, Dominant Perinatal Lethal
Epilepsy, Nocturnal Frontal Lobe, 2	Epilepsy, Nocturnal Frontal Lobe, Type 2 Autosomal Dominant Nocturnal Frontal Lobe Epilepsy 2 ENFL2 Nocturnal Frontal Lobe Epilepsy 2
Dentinogenesis Imperfecta	Hereditary Opalescent Dentin Dentinogenesis Imperfecta Without Osteogenesis Imperfecta Dgi Capdepont Teeth Dgi Without Oi Di Non-Syndromic Dgi Non-Syndromic Dentinogenesis Imperfecta Opalescent Teeth Without Oi Opalescent Teeth Without Osteogenesis Imperfecta Opalescent Dentin
Osteoporosis-Pseudoglioma Syndrome	OPPG Ops Osteoporosis With Pseudoglioma Osteogenesis Imperfecta, Ocular Form Ocular Form Of Osteogenesis Imperfecta Osteogenesis Imperfecta Ocular Form Osteoporosis Pseudoglioma Syndrome Pseudoglioma With Bone Fragility
Brittle Cornea Syndrome 1	Brittle Cornea Syndrome Fragilitas Oculi With Joint Hyperextensibility Dysgenesis Mesodermalis Corneae Et Sclerae BCS1 Corneal Fragility, Keratoglobus, Blue Sclerae, Joint Hyperextensibility Ehlers-Danlos Syndrome, Type Vib, Formerly Eds6b, Formerly Type Vib Ehlers-Danlos Syndrome Eds Vib Ehlers-Danlos Syndrome Type 6b Corneal Fragility Keratoglobus Blue Sclerae Joint Hyperextensibility Eds6b Formerly Ehlers-Danlos Syndrome Type Vib Formerly Ehlers-Danlos Syndrome Type 6 Cornea, Brittle, Syndrome Cornea, Brittle, Syndrome, Type 1 Ehlers-Danlos Syndrome 6b
Brittle Bone Disorder	Osteogenesis Imperfecta Brittle Bone Disease Fragilitas Ossium Osteopsathyrosis Lobstein Disease Oi Vrolik Disease Lobstein'S Disease Lobstein'S Syndrome Vrolik'S Disease Porak And Durante Disease Glass Bone Disease Osteogenesis Imperfecta, Dominant Perinatal Lethal Osteogenesis Imperfecta, Recessive Perinatal Lethal Brittle Bone Syndrome Oi - [Osteogenesis Imperfecta] Ossium Fragility Osteitis Fragilitans Bony Fragility Blue Sclera With Fragility Of Bone And Deafness White Blue Sclera - Fragility Of Bone - Deafness
Respiratory Failure	Acute Respiratory Failure Chronic Respiratory Failure Respiratory Insufficiency Acute-On-Chronic Respiratory Failure Respiratory Disease Acute And Chronic Respiratory Failure Respiratory Insufficiency/Failure Chronic Respiratory Disease Pulmonary Valve Insufficiency Chronic Disease Of Respiratory System Respiration Disorders Respiratory Tract Diseases Lung Failure Nos Pulmonary Failure Arf - [Acute Respiratory Failure] Acute Respiratory Insufficiency Acute Pulmonary Insufficiency Acute Respiration Failure Chronic Respiration Failure
Tooth Agenesis	Oligodontia Hypodontia Selective Tooth Agenesis Tooth Agenesis, Selective Familial Tooth Agenesis Anodontia Congenital Absence Of One Tooth

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-D0858S	MES-d13		99.93%	Unkown
HY-RS08341	MESD Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19918	Mesd Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26419	Mesd Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	MESD	VGNC	VGNC:63452
Mus musculus	MESD	MGD	MGI:1891421
Rattus norvegicus	MESD	RGD	RGD:1310344
Macaca mulatta	MESD	VGNC	VGNC:74507
Bos taurus	MESD	VGNC	VGNC:31392
Others	MESD	NCBI