ATP6V1E2 - ATPase H+ transporting V1 subunit E2 Gene

Also Known as VMA4; ATP6E1; ATP6EL2; ATP6V1EL2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 90423

Summary

Predicted to enable proton-transporting ATPase activity, rotational mechanism. Predicted to be involved in regulation of macroautophagy. Predicted to act upstream of or within proton transmembrane transport. Predicted to be located in cytosol. Predicted to be part of proton-transporting two-sector ATPase complex, catalytic domain. [provided by Alliance of Genome Resources, Jul 2025]
Broad expression in testis (RPKM 6.7), thyroid (RPKM 1.5) and 20 other tissues.

ATP6V1E2 Products (4)

mRNA Protein Name
NM_001318063.2 NP_001304992.1 V-type proton ATPase subunit E 2
NM_001371281.1 NP_001358210.1 V-type proton ATPase subunit E 2
NM_001371282.1 NP_001358211.1 V-type proton ATPase subunit E 2
NM_001371283.1 NP_001358212.1 V-type proton ATPase subunit E 2

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
21516116 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ATP6V1E2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ATP6V1E2 Q96A05 ATP6V1G2 Homo sapiens O95670
Y2H Prey Pooling
32296183
Intra
ATP6V1E2 Q96A05 ATP6V1G2 Homo sapiens O95670
Y2H Array
32296183
Intra
ATP6V1E2 Q96A05 MESD Homo sapiens Q14696
Y2H Prey Pooling
32296183
Intra
ATP6V1E2 Q96A05 MESD Homo sapiens Q14696
Y2H Array
32296183
Intra
ATP6V1E2 Q96A05 ATP6V1G1 Homo sapiens O75348
Crosslink
30021884
Intra
ATP6V1E2 Q96A05 ATP6V1G1 Homo sapiens O75348
Y2H Array
25416956
Intra
ATP6V1E2 Q96A05 ATP6V1G1 Homo sapiens O75348
Y2H
21516116
Intra
ATP6V1E2 Q96A05 BBLN Homo sapiens Q9BUW7
Y2H Prey Pooling
25416956
Intra
ATP6V1E2 Q96A05 BBLN Homo sapiens Q9BUW7
Validated Y2H
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01225 ATP6V1B2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01227 ATP6V1C2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01229 ATP6V1E1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01232 ATP6V1G2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown