ZNF827 - zinc finger protein 827 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 152485

About ZNF827

Cytogenetic location: 4q31.21-q31.22 Genomic coordinates (GRCh38): 4:145,757,627-145,938,823 (from NCBI)

This gene has 22 transcripts (splice variants), 236 orthologues and 36 paralogues. Ubiquitous expression in prostate (RPKM 4.9), thyroid (RPKM 2.3) and 23 other tissues.

Summary

Predicted to enable DNA binding activity and metal ion binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

ZNF827 Products (3)

mRNA Protein Name
NM_001306215.2 NP_001293144.1 zinc finger protein 827 isoform 1
NM_001410850.1 NP_001397779.1 zinc finger protein 827 isoform 3
NM_178835.5 NP_849157.2 zinc finger protein 827 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables NuRD complex binding IDA
IDA: Inferred from direct assay
25150861 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25150861 GOA
Biological Process GO Annotation Evidence References Source
involved in chromatin remodeling IMP
IMP: Inferred from mutant phenotype
25150861 GOA
involved in establishment of protein localization to telomere IMP
IMP: Inferred from mutant phenotype
25150861 GOA
involved in negative regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
33174841 GOA
involved in negative regulation of shelterin complex assembly IMP
IMP: Inferred from mutant phenotype
25150861 GOA
involved in telomere maintenance IMP
IMP: Inferred from mutant phenotype
25150861 GOA
Cellular Component GO Annotation Evidence References Source
located in chromatin IDA
IDA: Inferred from direct assay
33174841 GOA
located in chromosome, telomeric region IDA
IDA: Inferred from direct assay
25150861 GOA
part of ribonucleoprotein complex IDA
IDA: Inferred from direct assay
33174841 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZNF827 Protein Structure

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (390 - 412)

zf-C2H2

zf-C2H2: Zinc finger, C2H2 type (817 - 839)

zf-H2C2_5

zf-H2C2_5: C2H2-type zinc-finger domain (845 - 867)

zf-H2C2_5

zf-H2C2_5: C2H2-type zinc-finger domain (930 - 953)

zf-C2H2_4

zf-C2H2_4: C2H2-type zinc finger (1019 - 1041)

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  • 1000
  • 1081 a.a.
Protein Preferred Names Protein Names

zinc finger protein 827

ZNF827 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ZNF827 Q17R98 MTA2 Homo sapiens O94776
Anti Bait CoIP
25150861
Intra
ZNF827 Q17R98 HDAC2 Homo sapiens Q92769
Anti Bait CoIP
25150861
Intra
ZNF827 Q17R98 RBBP7 Homo sapiens Q16576
Anti Bait CoIP
25150861
Intra
ZNF827 Q17R98 CHD4 Homo sapiens Q14839
Anti Bait CoIP
25150861
Intra
ZNF827 Q17R98 MESD Homo sapiens Q14696
Y2H Array
32296183
Intra
ZNF827 Q17R98 MESD Homo sapiens Q14696
Y2H Prey Pooling
32296183
Intra
ZNF827 Q17R98 GATAD2B Homo sapiens Q8WXI9
Anti Bait CoIP
25150861
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS16177 ZNF827 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus ZNF827 MGD MGI:2444807
Bos taurus ZNF827 VGNC VGNC:55765
Macaca mulatta ZNF827 VGNC VGNC:100288
Rattus norvegicus ZNF827 RGD RGD:1560620
Felis catus ZNF827 VGNC VGNC:80125
Canis familiaris ZNF827 VGNC VGNC:106620