RBBP7 - RB binding protein 7, chromatin remodeling factor Gene

Also Known as RbAp46

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5931

About RBBP7

Cytogenetic location: Xp22.2 Genomic coordinates (GRCh38): X:16,844,341-16,870,362 (from NCBI)

This gene has 12 transcripts (splice variants), 234 orthologues and 9 paralogues. Ubiquitous expression in adrenal (RPKM 151.2), testis (RPKM 63.0) and 24 other tissues.

Summary

This protein is a ubiquitously expressed nuclear protein and belongs to a highly conserved subfamily of WD-repeat proteins. It is found among several proteins that binds directly to retinoblastoma protein, which regulates cell proliferation. The encoded protein is found in many histone deacetylase complexes, including mSin3 co-repressor complex. It is also present in protein complexes involved in chromatin assembly. This protein can interact with BRCA1 tumor-suppressor gene and may have a role in the regulation of cell proliferation and differentiation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

RBBP7 Products (2)

mRNA	Protein	Name
NM_001198719.2	NP_001185648.1	histone-binding protein RBBP7 isoform 1
NM_002893.4	NP_002884.1	histone-binding protein RBBP7 isoform 2

RBBP7 Protein Structure

CAF1C_H4-bd

WD40

0
100
200
300
400
425 a.a.

Protein Preferred Names	Protein Names
histone-binding protein RBBP7	G1/S transition control protein-binding protein RbAp46

RBBP7 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	RBBP7	Q16576	MTA2	Homo sapiens	O94776	TAP	27705803
Intra	RBBP7	Q16576	MTA2	Homo sapiens	O94776	Anti Tag CoIP	33961781
Intra	RBBP7	Q16576	MTA2	Homo sapiens	O94776	Anti Tag CoIP	28514442
Intra	RBBP7	Q16576	MTA2	Homo sapiens	O94776	TAP	24981860
Intra	RBBP7	Q16576	HDAC1	Homo sapiens	Q13547	TAP	27705803
Intra	RBBP7	Q16576	HDAC1	Homo sapiens	Q13547	Anti Tag CoIP	33961781
Intra	RBBP7	Q16576	HDAC1	Homo sapiens	Q13547	Anti Tag CoIP	28514442
Cross	RBBP7	Q16576	h4_xenla	Crosspus laevis	P62799	GMS	18571423
Cross	RBBP7	Q16576	h4_xenla	Crosspus laevis	P62799	Crosslink	18571423

Cross: Cross-species interaction Intra: Intraspecies interaction

RBBP7 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P84614	RBBP7 Antibody (YA4311)	WB, IHC-P, ICC/IF, FC, ELISA	Human, Mouse, Rat
HY-P84614A	RBBP7 Antibody (YA4311)(PBS only)	WB, IHC-P, ICC/IF, FC, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Retinoblastoma	RB Trilateral Retinoblastoma RB1 Retinoblastoma, Trilateral Neuroblastoma Of Retina Rb - Retinoblastoma Eye Cancer, Retinoblastoma Retinal Cancer Retinal Tumor Glioma, Retinal Non-Hereditary Retinoblastoma Childhood Cancer Retinoblastoma Malignant Neoplasm Of Retina Retinal Neoplasms
Hutchinson-Gilford Progeria Syndrome	Progeria HGPS Hutchinson-Gilford Syndrome Hutchinson-Gilford Progeria Hutchinson Gilford Syndrome Hutchinson Gilford Progeria Syndrome Hutchinson-Gilford Disease Progeria Of Childhood Hutchinson-Gilford-Progeria Syndrome
Weaver Syndrome	Wss Weaver-Smith Syndrome WVS Weaver-Like Syndrome Weaver-Williams Syndrome Camptodactyly-Overgrowth-Unusual Facies Syndrome Camptodactyly - Overgrowth - Unusual Facies Ezh2 Related Overgrowth Overgrowth Syndrome With Accelerated Skeletal Maturation, Unusual Facies, And Camptodactyly Weaver Smith Syndrome Weaver Like Syndrome Weaver Williams Syndrome Camptodactyly-Overgrowth-Unusual Facies Weaver Syndrome 1 Weaver Syndrome 2 Wvs1 Wvs2

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11719	RBBP7 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21723	Rbbp7 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28241	Rbbp7 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	RBBP7	RGD	RGD:620125
Mus musculus	RBBP7	MGD	MGI:1194910
Macaca mulatta	RBBP7	VGNC	VGNC:76678
Felis catus	RBBP7	VGNC	VGNC:69258
Bos taurus	RBBP7	VGNC	VGNC:33772
Canis familiaris	RBBP7	VGNC	VGNC:45393