TREX2 - three prime repair exonuclease 2 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 11219

About TREX2

Cytogenetic location: Xq28 Genomic coordinates (GRCh38): X:153,444,473-153,446,056 (from NCBI)

This gene has 7 transcripts (splice variants), 176 orthologues and 1 paralogue. Biased expression in skin (RPKM 5.9), spleen (RPKM 0.7) and 5 other tissues.

Summary

This gene encodes a nuclear protein with 3' to 5' exonuclease activity. The encoded protein participates in double-stranded DNA break repair, and may interact with DNA Polymerase delta. [provided by RefSeq, Nov 2012]

TREX2 Products (1)

mRNA	Protein	Name
NM_080701.4	NP_542432.2	three prime repair exonuclease 2

TREX2 Protein Structure

RNase_T

0
100
200
279 a.a.

Protein Preferred Names	Protein Names
three prime repair exonuclease 2	3'-5' exonuclease TREX2 long form

TREX2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TREX2	Q9BQ50	MESD	Homo sapiens	Q14696	Y2H Array	32296183
Intra	TREX2	Q9BQ50	MESD	Homo sapiens	Q14696	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Laryngeal Benign Neoplasm	Laryngeal Tumor Larynx Neoplasm Neoplasm Of Larynx Laryngeal Cancer Laryngeal Carcinoma Cancer Of Larynx
Intellectual Developmental Disorder, X-Linked 109	Fraxe Syndrome Fragile Xe Syndrome Mental Retardation, X-Linked, Fraxe Type XLID109 Mrx109 Mental Retardation, X-Linked, Associated With Fragile Site Fraxe Fraxe Mental Retardation Syndrome X-Linked Intellectual Developmental Disorder 109 Fraxe Intellectual Disability Fraxe Mental Retardation, X-Linked 109 Fragile Site On Chromosome Xq28 Fragile Site, Folic Acid Type X-Linked Intellectual Disability Associated With Fragile Site Fraxe Fraxe Intellectual Deficit Intellectual Disability Associated With Fragile Site Fraxe

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15009	TREX2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-160786	TREX1-IN-3	Inhibitor	/	Unkown
HY-160786A	TREX1-IN-4	Inhibitor	/	Unkown
HY-RS22876	Trex2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS29390	Trex2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	TREX2	MGD	MGI:1346343
Rattus norvegicus	TREX2	RGD	RGD:1562245
Canis familiaris	TREX2	VGNC	VGNC:54379
Felis catus	TREX2	VGNC	VGNC:66523
Others	TREX2	NCBI